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We established a hypertension and hypercholesterolemia model via feeding a high salt diet (8% NaCl, HSD) to Dahl salt\u2010sensitive (SS) rats for 5 weeks. This diet regime successfully induced hypertension and increased serum TC and LDL\u2010C. RNA\u2010seq and RT\u2010qPCR analyses confirmed that activation of cholesterol biosynthesis in liver tissues by an HSD led to elevated serum cholesterol levels. In vivo experiments suggested that the HSD\u2010induced elevation of serum IL\u201017 likely contributes to hypertension and dyslipidemia as a co\u2010pathogenic factor. Knockdown or overexpression of IL\u201017RA in HepG2 cells and HUVECs further confirmed that upregulating this signaling pathway promotes the nuclear entry of SREBP2, a protein critical to cholesterol biosynthesis. In HUVECs, IL\u201017RA inhibition enhanced NO production, whereas IL\u201017RA overexpression suppressed it. Administration of rat\u2010specific anti\u2010IL\u201017A antibody significantly attenuated salt\u2010induced hypertension and reduced serum TC and LDL\u2010C levels. These findings demonstrate that a high\u2010salt diet elevates the risk of hypertension and hypercholesterolemia by activating IL\u201017 signaling pathway. This suggests that IL\u201017A inhibitors may serve as potential therapeutic agents for treating salt\u2010induced hypertension and hypercholesterolemia.<\/jats:p>","DOI":"10.1002\/mnfr.70171","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T05:40:41Z","timestamp":1752126041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interleukin\u201017A Exacerbates the Development of High\u2010Salt\u2010Induced Hypercholesterolemia"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-8930","authenticated-orcid":false,"given":"Yanan","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Urology Xi'an People's Hospital (Xi'an Fourth Hospital) School of Life Sciences and Medicine Northwest University  Xi'an Shaanxi China"},{"name":"Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life 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