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Pea protein hydrolysate (PPH), a kind of bioactive peptide with anti\u2010diabetic properties, was evaluated for its therapeutic potential in the GDM mouse model. While PPH exhibited mild glucose\u2010lowering effects, high\u2010dose PPH (1000\u00a0mg\/kg\/day) significantly ameliorated insulin resistance and systemic dyslipidemia, including reductions in serum triglycerides, total cholesterol, low\u2010density lipoprotein cholesterol, and hepatic lipid accumulation. In addition, the PPH treatment could significantly modulate the placental pathology. Thus, a mechanistic study was conducted from the view of placental lipid metabolism. It was found that the inhibition of the PI3K\/AKT\/mTOR\/PPAR\u03b3 signaling pathway was involved in the mechanisms of action of PPH, which successfully prevented excessive placental lipid accumulation and ensured that the key structures of the placenta remained in the original state. Furthermore, PPH alleviated the GDM\u2010induced reduction in placental phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels, restoring two functionally critical lipid species: PC (16:0\/20:4) and FAHFA (26:1\/22:3). Collectively, PPH showed the potential to mitigate GDM\u2010associated metabolic disturbances and placental dysfunction.<\/jats:p>","DOI":"10.1002\/mnfr.70178","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T05:39:59Z","timestamp":1752125999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Regulatory Effects of Pea Protein Hydrolysate on Lipid Metabolism in Gestational Diabetic Mice"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9479-4692","authenticated-orcid":false,"given":"Tingqing","family":"Yu","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing Jiangsu 210009 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