{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:04:26Z","timestamp":1783397066841,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Unbalanced lipid metabolism contributes to inflammation in several conditions. Gluten, that triggers celiac disease, may also play a role in diseases associated with a high\u2010fat diet (HFD). Our aim was to investigate the interplay between gluten and HFD in HLA\u2010DQ8 (DQ8) transgenic mice, a model of gluten sensitivity. DQ8 mice were fed the gluten\u2010free diet, the HFD, or the HFD containing 8% gluten (HFD\u00a0+\u00a0G) for 12 or 23 weeks. Clinical parameters, liver and intestinal histology, immune parameters were assessed. Twelve weeks of HFD increased body and white adipose tissue weight and reduced glucose tolerance in male DQ8 mice. Gluten increased hyperinsulinemia and lipid accumulation in liver; interferon gamma (IFN\u2010\u03b3) and interleukin\u201010 (IL\u201010) transcripts were higher in liver of HFD\u00a0+\u00a0G\u2010fed mice. IL\u20101\u03b2, tumor necrosis factor\u2010\u03b1\u00a0(TNF\u2010\u03b1), IFN\u2010\u03b3, and IL\u201010 mRNAs increased in the small intestine of HFD\u00a0+\u00a0G\u2010fed mice. However, gliadin\u2010specific immunity and alterations of the intestinal architecture were not induced. Feeding HFD\u00a0+\u00a0G for 23 weeks attenuated the gluten effect. A synergic effect between gluten and HFD after 12 weeks was found, which was instrumental to alter specific metabolic and immune functions in DQ8 mice. These findings provide new insights useful to dissect the association between obesity and gluten sensitivity.<\/jats:p>","DOI":"10.1002\/mnfr.70221","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T05:47:04Z","timestamp":1756100824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010Fat Diet\u2013Wheat Gluten Interactions in HLA\u2010DQ8 Transgenic Mice"],"prefix":"10.1002","volume":"69","author":[{"given":"Yuri","family":"Haneishi","sequence":"first","affiliation":[{"name":"Department of Applied Biological Science Graduate School of Agriculture Tokyo University of Agriculture and Technology  Fuchu\u2010shi Tokyo Japan"},{"name":"Department of International Food and Agricultural Science Faculty of International Agriculture and Food Studies Tokyo University of Agriculture  Setagaya\u2010ku Tokyo 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