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Although managed by a gluten\u2010free diet (GFD), symptoms persist in 30%\u201350% of treated individuals despite apparent dietary compliance. Accordingly, the present review explores how bifidobacteria may mediate cytotoxic and proinflammatory responses induced by gluten\u2010derived peptides, contributing to the modulation of CD symptoms. Experimental in vitro studies, primarily using Caco\u20102 cells and immune cell models, have shown that strains such as\n                    <jats:italic>Bifidobacterium longum<\/jats:italic>\n                    IATA\u2010ES1,\n                    <jats:italic>Bifidobacterium lactis<\/jats:italic>\n                    ,\n                    <jats:italic>Bifidobacterium bifidum<\/jats:italic>\n                    IATA\u2010ES2, and\n                    <jats:italic>B. lactis<\/jats:italic>\n                    Natren Life Start super strain (NLS\u2010SS) can induce COX\u20101 expression and reduce COX\u20102, inhibit zonulin release, degrade gliadin\u2010derived peptides, and suppress CXCR3 mRNA expression and inflammatory mediators (e.g., TNF\u2010\u03b1, IFN\u2010\u03b3, NF\u2010\u03baB, and IL\u20101\u03b2). Animal studies have provided evidence of immunomodulatory effects and improved mucosal responses, while human clinical trials have reported improvements in gastrointestinal symptoms and inflammatory markers with probiotic interventions. These findings support the potential of\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    spp. as adjunctive agents in CD management. However, further clinical research is needed to clarify strain\u2010specific effects and confirm the translational relevance of these mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70222","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T05:31:52Z","timestamp":1756704712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten\u2010Induced Cytotoxicity and Inflammation"],"prefix":"10.1002","volume":"69","author":[{"given":"Taynara Cipriano","family":"Scherer","sequence":"first","affiliation":[{"name":"Department of Pharmacy Health Sciences Center Federal University of Santa Catarina  Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology 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