{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:06:22Z","timestamp":1779123982259,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005322","name":"Recep Tayyip Erdogan \u00dcniversitesi","doi-asserted-by":"publisher","award":["TYL\u20102020\u20101161"],"award-info":[{"award-number":["TYL\u20102020\u20101161"]}],"id":[{"id":"10.13039\/501100005322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Sortilin regulates lipid metabolism, adipogenesis, and inflammation in obesity. While the anti\u2010inflammatory and lipid\u2010modulating effects of krill oil (KO) on obesity are well known, its effects on sortilin remain insufficiently investigated. This study investigates the potential effects of KO supplementation on sortilin and pro\u2010inflammatory cytokine levels in rats fed a high\u2010fat diet (HFD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Twenty\u2010four male Sprague Dawley rats were randomly assigned to three groups: standard diet (SD), HFD, and HFD\u00a0+\u00a0KO (600\u00a0mg\/kg\/day KO via oral gavage for 12 weeks). Body weights were monitored weekly. Serum total cholesterol (TC), triglyceride, glucose, insulin, and HOMA\u2010IR were measured. Sortilin, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 levels were assessed in liver and retroperitoneal (RP) adipose tissues. The HFD group showed significant increases in weight, TC, glucose, and HOMA\u2010IR, with decreased hepatic and increased RP adipose sortilin and TNF\u2010\u03b1 levels. KO reduced serum TC, increased hepatic sortilin and TNF\u2010\u03b1, and decreased their levels in RP adipose tissue. These findings indicate that KO exerts a protective effect against HFD\u2010induced obesity and inflammation by modulating lipid metabolism, reducing TNF\u2010\u03b1 and sortilin levels. Therefore, KO may serve as a promising dietary intervention for mitigating obesity\u2010related metabolic and inflammatory complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.70233","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T08:22:16Z","timestamp":1756542136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of the Effect of Krill Oil on Sortilin in Liver and Adipose Tissue in Obese Rats"],"prefix":"10.1002","volume":"69","author":[{"given":"Mehtap","family":"Atak","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine Recep Tayyip Erdogan University  Rize Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Beyza","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine Recep Tayyip Erdogan University  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