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Our findings highlighted the antioxidant properties of these extracts through various assays and demonstrated potential biochemical effects in ALI mice. We explored the impact of the fermentation extracts on gut microbiota, revealing both quantitative and qualitative modifications through 16S rDNA amplicon sequencing of intestinal flora. The fermentation extracts exhibited antioxidant and anti\u2010inflammatory effects while also regulating lipid metabolism. Research indicates that differences in gut microbiota composition affect susceptibility to ALI. The unique OTUs identified in the three groups (Normal, EtOH, and High CK) were 108, 60, and 62, respectively. These fermentation extracts positively influenced specific gut microbiota by increasing the abundance of advantageous microorganisms such as\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    ,\n                    <jats:italic>Adlercreutzia, Lactobacillus<\/jats:italic>\n                    , and\n                    <jats:italic>Angelakisella<\/jats:italic>\n                    within the gut microenvironment. In conclusion, this research enhances our understanding of the mechanisms underlying the fermentation of jujube fruit with Cordyceps fungi, the pathogenesis of ALI, and the functional role of intestinal microbiota.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70243","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T07:04:38Z","timestamp":1758351878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cordyceps\u2010Fermented Chinese Jujube Ameliorates Oxidative Stress and Restores Gut Microbiome in Alcohol\u2010Induced Liver Injury in Mice"],"prefix":"10.1002","volume":"69","author":[{"given":"Tin Ei","family":"Cho","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianya","family":"Ling","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology Shandong University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2021.02.010"},{"issue":"2","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.35946\/arcr.v38.2.01","article-title":"Alcoholic Liver Disease: Pathogenesis and Current Management","volume":"38","author":"Osna N. 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