{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:30:47Z","timestamp":1790285447499,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    HPV infection is a major global health concern, and recent evidence suggests that the gut microbiota may play a critical role in HPV progression and clearance. This study aimed to evaluate the modulatory effects of the probiotic strain\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    Probio87 on the gut bacterial composition of HPV\u2010positive women. A 12\u2010week randomized, placebo\u2010controlled trial was conducted in accordance with the Declaration of Helsinki, with ethical approval from the Medical Research and Ethics Committee, Ministry of Health Malaysia (NMRR\u201021\u20101819\u201061300), and registration at ClinicalTrials.gov (NCT05316064). Probiotic supplementation with\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    Probio87 significantly modulated the gut microbiota. Specifically, reductions were observed in the relative abundance of potentially pathogenic bacteria, including\n                    <jats:italic>Gardnerella vaginalis<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.055),\n                    <jats:italic>Fannyhessea vaginae<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.039), and\n                    <jats:italic>Bilophila<\/jats:italic>\n                    species (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.008). Conversely, levels of beneficial microbes such as\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001),\n                    <jats:italic>Anaerotignum lactatifermentans<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.039),\n                    <jats:italic>Blautia faecis<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.061), and\n                    <jats:italic>Roseburia hominis<\/jats:italic>\n                    A2\u2010183 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.052) were elevated. These findings suggest that\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    Probio87 promotes gut microbial balance by reducing dysbiosis\u2010associated bacteria and enhancing beneficial populations. This modulation may contribute to improved vaginal and overall health in women with HPV infection.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70247","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T07:40:07Z","timestamp":1756539607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Probiotic\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    Probio87 Improves Gut Microbial Profiles in HPV\u2010Positive Women: A Randomized, Placebo\u2010Controlled and Double\u2010Blind Study"],"prefix":"10.1002","volume":"69","author":[{"given":"Pei","family":"Xu","sequence":"first","affiliation":[{"name":"College of Culinary and Food Science Engineering Sichuan Tourism University  Chengdu China"},{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mageswaran 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