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In the animal study, Sprague\u2010Dawley rats were divided into five groups (control, model, PS, PL, and PS+PL) and treated for 8 weeks. The PS+PL combination significantly reduced body weight, liver index, and serum glutathione peroxidase activity, while improving hepatic and adipose morphology. In the human trial, 82 participants were randomized into PS, PS+PL, or placebo groups and treated for 2 months in a triple\u2010blind, parallel\u2010design trial. Both PS and PS+PL groups showed significant reductions in total cholesterol, low\u2010density lipoprotein cholesterol, alanine aminotransferase, reactive oxygen species, and lipid peroxidation, along with improvements in antioxidant enzyme and lipase activities. The PS+PL group showed additional effects, including reduced apolipoprotein B and lactate dehydrogenase levels, demonstrating superior efficacy compared to PS alone. In conclusion, PSs, particularly when combined with PLs, effectively improve cholesterol profile and oxidative stress parameters. These findings highlight the potential translational benefits of PS+PL as a functional dietary intervention for managing borderline hypercholesterolemia.<\/jats:p>","DOI":"10.1002\/mnfr.70248","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:32:53Z","timestamp":1756895573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phytosterols and Phospholipids Synergistically Improve Lipid Metabolism and Oxidative Stress: Evidence From Animal Model and Human Randomized Controlled Trials"],"prefix":"10.1002","volume":"69","author":[{"given":"Yusi","family":"Gao","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health Southeast University  Nanjing China"},{"name":"Wuxi Xishan District Center for Disease Control and Prevention  Wuxi Jiangsu 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