{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:17:28Z","timestamp":1789586248820,"version":"build-2803163510"},"reference-count":151,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early\u2010life programming is a major determinant of lifelong metabolic health, yet current preventive strategies focus almost exclusively on maternal factors. Emerging experimental and preclinical data reveal that a father's diet before conception, particularly high\u2010fat intake, also shapes offspring physiology. Here, we synthesize the latest evidence on how such diets remodel the sperm epigenome during two discrete windows of vulnerability: (i) testicular spermatogenesis, via DNA methylation and histone modifications, and (ii) post\u2010testicular epididymal maturation, where small non\u2010coding RNAs are selectively gained. We examine how these epigenetic signals influence pregnancy, placental development, and ultimately, metabolic trajectories in progeny. To extend published work, we sourced publicly available diet\u2010induced sperm epigenome datasets and provide new potential connections of these changes to genes governing placental development, vascularization and size using the International Mouse Phenotyping Consortium data. Moreover, we further interrogate these overlaps with intricate in\u2010silico analyses to examine their potential consequences. To foster meaningful interactions with these findings, we have developed a web application for ease (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/reproproteomics.shinyapps.io\/ShinySpermPlacenta\/\">ShinySpermPlacenta<\/jats:ext-link>\n                    ). Collectively, these findings support a biparental model of preconception care and position the sperm epigenome as a promising tractable biomarker platform for personalized paternal nutrition counselling aimed at improving fertility and reducing intergenerational metabolic disease risk.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70261","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T12:46:01Z","timestamp":1757162761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health"],"prefix":"10.1002","volume":"69","author":[{"given":"David A.","family":"Skerrett\u2010Byrne","sequence":"first","affiliation":[{"name":"Institute of Experimental Genetics Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health  Neuherberg Germany"},{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"},{"name":"Infertility and Reproduction Research Program Hunter Medical Research Institute  New Lambton Heights NSW Australia"},{"name":"School of Biomedical Sciences and Pharmacy College of Health Medicine and Wellbeing The University of Newcastle Callaghan  Awabakal Country NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sophie","family":"Pepin","sequence":"additional","affiliation":[{"name":"Institute of Functional Epigenetics Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Laurent","sequence":"additional","affiliation":[{"name":"Institute of Experimental Genetics Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health  Neuherberg Germany"},{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Beckers","sequence":"additional","affiliation":[{"name":"Institute of Experimental Genetics Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health  Neuherberg Germany"},{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"},{"name":"Chair of Experimental Genetics TUM School of Life Sciences Technische Universit\u00e4t M\u00fcnchen  Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schneider","sequence":"additional","affiliation":[{"name":"Institute of Functional Epigenetics Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"},{"name":"Faculty of Biology Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Planegg\u2010Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"},{"name":"Chair of Experimental Genetics TUM School of Life Sciences Technische Universit\u00e4t M\u00fcnchen  Freising Germany"},{"name":"Institute of Experimental Genetics German Mouse Clinic Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health (GmbH)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Teperino","sequence":"additional","affiliation":[{"name":"Institute of Experimental Genetics Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health  Neuherberg Germany"},{"name":"German Center for Diabetes Research (DZD)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13552"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4919-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13603"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0558"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0769"},{"key":"e_1_2_11_7_1","first-page":"1428886","volume-title":"Frontiers Media SA","author":"Xie X.","year":"2024"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00187"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2014.9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-024-00258-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-020-09839-z"},{"key":"e_1_2_11_12_1","volume-title":"Overweight and Obesity by Sex, Age, and Educational Attainment Level (% of Population With BMI \u2265 25)","author":"Eurostat E. 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