{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T14:35:43Z","timestamp":1765550143657,"version":"3.48.0"},"reference-count":44,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Amblyopia is a neurodevelopmental disorder characterized by impaired vision in childhood and remains challenging to manage effectively. The present study investigated the neuroprotective potential of\n                    <jats:italic>Rubus idaeus<\/jats:italic>\n                    L. (red raspberry) in a rodent model of amblyopia. Through network pharmacology analysis, the PI3K\/AKT axis was identified as a major regulatory target of\n                    <jats:italic>R. idaeus<\/jats:italic>\n                    L. treatment. In vitro, 1\u00a0\u00b5g\/mL of\n                    <jats:italic>R. idaeus<\/jats:italic>\n                    L. significantly enhanced neuronal survival under oxidative stress (82.4%\u00a0vs. 54.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) and reduced apoptotic cell death by 23.5% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). These protective effects correlated with elevated expression of anti\u2010apoptotic proteins (Bcl\u20102, PI3K) and decreased levels of pro\u2010apoptotic markers (Bax, cleaved caspase\u20103). In vivo,\n                    <jats:italic>R. idaeus<\/jats:italic>\n                    L. treatment improved visual evoked potentials in a monocular deprivation model, indicated by shorter P\n                    <jats:sub>100<\/jats:sub>\n                    latency and increased amplitude. These effects were reversed by the PI3K inhibitor LY294002, supporting the involvement of the PI3K\/AKT axis. Our findings suggest that\n                    <jats:italic>R. idaeus<\/jats:italic>\n                    L. holds potential as a novel therapeutic approach for amblyopia via modulation of neuroprotective pathways.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70288","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:21:41Z","timestamp":1762762901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Effects of\n                    <i>Rubus idaeus<\/i>\n                    in Amblyopia"],"prefix":"10.1002","volume":"69","author":[{"given":"Ying","family":"Zhao","sequence":"first","affiliation":[{"name":"Ophthalmology The Second Affiliated Hospital of Shandong First Medical University  Tai'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yin","sequence":"additional","affiliation":[{"name":"Ophthalmology The Second Affiliated Hospital of Shandong First Medical University  Tai'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"627","article-title":"Binocular Treatment for Amblyopic Children: A Review","volume":"73","author":"Bokhary K. 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