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The 50 male Wistar rats were divided into five groups: G\n                    <jats:sub>0<\/jats:sub>\n                    as the negative control, G\n                    <jats:sub>1<\/jats:sub>\n                    as the positive control, G\n                    <jats:sub>2<\/jats:sub>\n                    as the standard drug group (mesalamine 500\u00a0mg\/kg), G\n                    <jats:sub>3<\/jats:sub>\n                    as the group receiving the control beverage (without particle enrichment), and G\n                    <jats:sub>4<\/jats:sub>\n                    as the group receiving the enriched beverage (0.15\u00a0mL\/day\/rat). The study duration was 21 days. Polyphenol\u2013protein particle\u2010enriched beverage ameliorated the disease activity index (DAI), weight loss, and colon weight\u2010to\u2010length ratio. Furthermore, it witnessed a reduction in ESR and CRP levels and improved hematological parameters. The following serum inflammatory markers were also decreased: TNF\u2010\u03b1 (49.52%), IL\u20101\u03b2 (46.13%), and IL\u20106 (55.72%). The oxidative stress was alleviated by reducing the levels of TOS (64.10%), MDA (40.71%), and MPO (83.32%) while enhancing the TAC (191.55%), GSH (47.89%), SOD (87.89%), and CAT (63.63%) levels. The polyphenol\u2013protein\u2010enriched beverage was also safe in terms of its effect on liver and kidney function markers. Also, polyphenol\u2013protein particle\u2010enriched beverage exerted regeneration in the histological damage in the colon. Bioaccessibility studies revealed higher total phenolic content and antioxidant activity in the digested fraction of the enriched beverage.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70295","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:46:29Z","timestamp":1761803189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory and Antioxidant Potential of\u00a0Polyphenol\u2013Protein Particle\u2010Enriched Beverage via Attenuating Biochemical Alterations and Colon Tissue Damage in Acetic Acid\u2010Induced Colitis in Rats"],"prefix":"10.1002","volume":"69","author":[{"given":"Sidra","family":"Tul\u2010Muntaha","sequence":"first","affiliation":[{"name":"National Institute of Food Science and Technology University of Agriculture  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allah","family":"Rakha","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology University of Agriculture  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Pasha","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology University of Agriculture  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Aslam","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science Institute of Physiology and Pharmacology University of Agriculture Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0268-7"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Treatment of Inflammatory Bowel Disease: A Comprehensive Review","volume":"8","author":"Cai Z.","year":"2021","journal-title":"Frontiers in Medicine"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0258-z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01386-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020305"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1390351"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13040573"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/md22080336"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.01.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622319899297"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01784-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1907607"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1570913"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.113573"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"K.Sharma N.Mahato M. 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