{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T14:36:15Z","timestamp":1765550175691,"version":"3.48.0"},"reference-count":65,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study explored the impact of aerobic and anaerobic exercise, combined with carnosine supplementation, on angiogenesis\u2010related biomarkers in cardiac and cerebral tissues. Forty\u2010five male Sprague\u2010Dawley rats were randomly allocated to seven groups: control (C), sham (S), carnosine (Cz), aerobic exercise (AE), anaerobic exercise (AnE), AE + Cz, and AnE + Cz. Exercise protocols were performed 5 days per week for 5 weeks (aerobic: 15\u00a0m\/min; anaerobic: 25\u00a0m\/min), while carnosine was administered orally (100\u00a0mg\/kg\/day). Biomarker levels of VEGF\u2010A, HIF\u20101\u03b1, Ang\u20101, MMP\u20109, tumstatin, and endostatin were measured using ELISA, and data were analyzed by ANOVA, Pearson correlation, PCA, and hierarchical clustering. The myocardial tissue revealed that VEGF\u2010A, HIF\u20101\u03b1, and Ang\u20101 significantly increased in exercise and combined groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), with AE + Cz showing the highest VEGF\u2010A and AnE + Cz the highest HIF\u20101\u03b1. The tumstatin and endostatin levels were significantly reduced in AE and AE + Cz groups. The brain tissue indicated that Ang\u20101 increased, while tumstatin and endostatin consistently decreased across all exercise groups. PCA and clustering analyses revealed a dominant pro\u2010angiogenic profile in AE + Cz and AnE + Cz, whereas C, S, and Cz groups showed anti\u2010angiogenic tendencies. Carnosine supplementation may represent a nutritionally relevant approach to modulate exercise\u2010induced angiogenic adaptations with possible implications for cardiovascular and neurovascular health.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70298","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T05:38:04Z","timestamp":1762407484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modulation of Angiogenesis\u2010Related Biomarkers in Brain and Myocardial Tissues by Exercise and Carnosine: An ELISA\u2010Based Analysis of VEGF\u2010A, HIF\u20101\u03b1, Ang\u20101, MMP\u20109, and Anti\u2010Angiogenic Factors"],"prefix":"10.1002","volume":"69","author":[{"given":"H\u00fcsne","family":"Bolat","sequence":"first","affiliation":[{"name":"Faculty of Sport Sciences F\u0131rat University  Elaz\u0131g T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taner","family":"Akbulut","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences F\u0131rat University  Elaz\u0131g T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedat","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences F\u0131rat University  Elaz\u0131g T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emsal \u00c7a\u011fla","family":"Avcu","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences Cumhuriyet University  Sivas T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz","family":"Yasul","sequence":"additional","affiliation":[{"name":"Bafra Vocational School Ondokuz May\u0131s University  Samsun T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Bozbay","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences F\u0131rat University  Elaz\u0131g T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine F\u0131rat University  Elazig T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.12.004"},{"key":"e_1_2_13_3_1","first-page":"706","article-title":"Hypoxia Inducible Factor\u20101 Alpha and Multiple Myeloma","volume":"4","author":"Bhaskar A.","year":"2016","journal-title":"International Journal of Advanced Research"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.001"},{"key":"e_1_2_13_5_1","first-page":"455","article-title":"Vascular Endothelial Growth Factor (VEGF)\u2014Key Factor in Normal and Pathological Angiogenesis","volume":"59","author":"Melincovici C. 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