{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:01:50Z","timestamp":1784026910681,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022\u2010139104OB\u2010I00"],"award-info":[{"award-number":["PID2022\u2010139104OB\u2010I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute pancreatitis (AP) severely disrupts gut microbiota, leading to dysbiosis. This study investigated whether kefir derived from pasteurized whole milk (PMK) or whey (WK) could mitigate AP\u2010induced gut microbiota alterations and promote gut health in a murine model. Male BALB\/cJRj mice were assigned to CONTROL, AP\u2010induced (PAN), PMK, WK, PMKPAN, or WKPAN groups. Fecal bacterial DNA was analyzed via 16S rRNA sequencing. AP induction caused characteristic dysbiosis, increasing Marinifilaceae, Tannerellaceae,\n                    <jats:italic>Odoribacter<\/jats:italic>\n                    , and\n                    <jats:italic>Parabacteroides<\/jats:italic>\n                    . In AP mice, PMK treatment significantly reduced Tannerellaceae and\u00a0\n                    <jats:italic>Parabacteroides<\/jats:italic>\n                    , while increasing potentially anti\u2010inflammatory\u00a0Marinifilaceae\u00a0and butyrate\u2010producing\u00a0\n                    <jats:italic>Odoribacter<\/jats:italic>\n                    . In healthy mice, PMK reduced pro inflammatory Desulfovibrionaceae\u00a0and\u00a0\n                    <jats:italic>Bilophila<\/jats:italic>\n                    , enriching short\u2010chain fatty acid (SCFA) producers like\u00a0\n                    <jats:italic>Acetatifactor<\/jats:italic>\n                    \u00a0and\u00a0\n                    <jats:italic>Roseburia<\/jats:italic>\n                    , with pathway analysis showing increased acetate kinase activity. WK treatment in healthy animals also promoted SCFA\u2010producers (\n                    <jats:italic>Acetatifactor<\/jats:italic>\n                    ,\u00a0\n                    <jats:italic>Odoribacter<\/jats:italic>\n                    ) and\u00a0Muribaculaceae. In the AP model, WK upregulated bacteria involved in fatty acid biosynthesis pathways. Dairy\u2010based kefir, particularly PMK, demonstrates a significant capacity to counteract AP\u2010induced gut microbiota imbalances. These findings highlight kefir's nutritional relevance as a functional food with potential preventive and therapeutic applications for supporting gut health in the context of AP.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70304","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:35:16Z","timestamp":1761762916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of Intestinal Microbiota Through Kefir\u2010Based Beverages in a Murine Model of Acute Pancreatitis"],"prefix":"10.1002","volume":"69","author":[{"given":"Diego","family":"Aguirre\u2010Ram\u00edrez","sequence":"first","affiliation":[{"name":"Departamento De Farmacolog\u00eda Fisiolog\u00eda y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Zaragoza  Zaragoza Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n IA2 (UNIZAR\u2010CITA)  Zaragoza Spain"},{"name":"Instituto De Investigaci\u00f3n Sanitaria De Arag\u00f3n (IIS Arag\u00f3n), Avda. 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