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Male Wistar rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06\/group) were assigned to the following four groups: control (C), control + GRE (100\u00a0mg\/kg), noise\u2010exposed (N), and noise\u2010exposed + GRE (N+GRE, 100\u00a0mg\/kg). Rats in the N and N+GRE groups were exposed to 90\u00a0dB(A) white noise for 2\u00a0h\/day for 28 days, with GRE administered orally throughout the exposure period. Phytochemical analysis confirmed the presence of flavonoids and phenolic acids with known antioxidant and anti\u2010inflammatory activities. In vitro, GRE significantly reduced nitric oxide production in lipopolysaccharide\u2010stimulated RAW264.7 macrophages. In vivo, noise exposure elevated cardiac malondialdehyde levels, impaired antioxidant enzyme activity, and increased circulating tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) and heme oxygenase\u20101 (HO\u20101) levels. GRE treatment restored redox balance, suppressed proinflammatory mediator levels, and improved histopathological alterations. Molecular docking analysis indicated strong binding of GRE phytoconstituents to HO\u20101 and TNF\u2010\u03b1, supporting the observed in vivo effects. These findings demonstrate that GRE mitigates noise\u2010induced cardiac injury through its antioxidant and anti\u2010inflammatory properties, highlighting its therapeutic potential\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70320","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T12:10:34Z","timestamp":1763381434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Alpinia galanga<\/i>\n                    Rhizome Extract Shields Against Noise\u2010Induced Cardiotoxicity via Antioxidant and Anti\u2010Inflammatory Actions: Experimental Insights"],"prefix":"10.1002","volume":"69","author":[{"given":"Takoua","family":"Ben Attia","sequence":"first","affiliation":[{"name":"Laboratory of Research \"LR 23\/ES\/10\": Population Pathology Environmental Aggressors Alternative Therapy Faculty of Medicine of Tunis University of Tunis El Manar  Tunis 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