{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T14:35:31Z","timestamp":1765550131639,"version":"3.48.0"},"reference-count":56,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD2101400"],"award-info":[{"award-number":["2022YFD2101400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dietary functional oligosaccharides exhibit anti\u2010inflammatory activity and regulatory impact on glucose metabolism. However, the protective effect of neoagarotetraose (NAT) against diabetes progression and the underlying molecular mechanisms remain unclear. This study investigated the hypoglycemic effect of NAT in diabetic mice. NAT was supplemented for 12 weeks in mice fed with a high\u2010fat diet (HFD). In HFD\u2010fed mice, NAT intervention (600\u00a0mg\/kg) reduced the fasting glucose and insulin concentrations by 35.9% and 30.1% (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.01), and improved systemic inflammation and dyslipidemia. Moreover, diabetic mice induced by a high\u2010fat and high\u2010sugar diet plus streptozotocin were administered NAT for 7 weeks. NAT treatment lowered the area under the oral glucose and insulin tolerance test curves by 31.0% and 48.9% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt; 0.01). NAT decreased the phosphorylation of nuclear factor kappa\u2010B to alleviate intestinal inflammation caused by diabetes mellitus. NAT reversed the derangements of hepatic glucose metabolism as evidenced by the activated AMPK\/PGC\u20101\u03b1 signaling pathway and decreased mRNA expression of inflammatory factors. Furthermore, the imbalanced gut microbiota of diabetic mice was reshaped by NAT treatment. NAT attenuates hyperglycemia through inflammation amelioration and glucose metabolism improvement, thus mitigating the development of diabetes mellitus in mice.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70323","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:49:33Z","timestamp":1763966973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoagarotetraose Attenuates Hyperglycemia Through Inflammation Amelioration and Glucose Metabolism Improvement"],"prefix":"10.1002","volume":"69","author":[{"given":"Jiaobo","family":"Cheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Food Bioengineering (China National Light Industry) College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaojuan","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Engineering China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Bioengineering (China National Light Industry) College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxuan","family":"Wu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Equipment Technology Chinese Academy of Agricultural Mechanization Science Group Co., Ltd  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxiao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Engineering China Agricultural University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengqiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Bioengineering (China National Light Industry) College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"},{"name":"Food Laboratory of Zhongyuan  Luohe China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113892037287976231212104607"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.025"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.909569"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-024-02335-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.04.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2023.03.017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105602"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00216"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02282-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c05163"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.10.012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0357-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.139552"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.04.014"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44252"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17100541"},{"key":"e_1_2_10_19_1","first-page":"1197","article-title":"Purification and Characterization of Neoagarotetraose from Hydrolyzed Agar","volume":"19","author":"Jang M. 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