{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T14:35:33Z","timestamp":1765550133091,"version":"3.48.0"},"reference-count":54,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study is to determine the effects of synbiotic buffalo kefirs on streptozotocin (STZ)\u2010induced in vivo type 1 diabetes mellitus markers. Kefir was produced by adding\n                    <jats:italic>Lactobacillus acidophilus, Bifidobacterium bifidum<\/jats:italic>\n                    , and fructooligosaccharide (FOS) to buffalo milk using DVS kefir culture. For the in vivo study, 70 male rats were fed buffalo kefir samples for 28 days. Physicochemical (pH, titration acidity, dry matter, fat, protein) and microbiological analyses were performed on kefir samples. Blood samples from the experimental animals were analyzed for malondialdehyde (MDA), superoxide dismutases (SOD), glutathione peroxidase (GPX), and diabetes parameters. The results showed that the probiotic bacterial count was highest in the sample containing FOS+\n                    <jats:italic>Lb. acidophilus<\/jats:italic>\n                    . In diabetic rats, triglyceride levels decreased significantly in the group consuming the FOS\n                    <jats:italic>+B. bifidum<\/jats:italic>\n                    sample. High\u2010density lipoprotein and total cholesterol levels remained unchanged. In groups consuming synbiotic buffalo kefir, a decrease in lipid peroxidation resulting from oxidative stress and significant increases in the activity of antioxidant defense enzymes SOD and GPX were detected. Synbiotic buffalo kefir samples reduced the MDA values in all diabetic groups. The findings suggest that consuming synbiotic buffalo kefir may help mitigate the effects of type 1 diabetes mellitus.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70324","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:45:43Z","timestamp":1763707543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Protective Effects of Synbiotic Buffalo Kefir in Rats With Type 1 Diabetes Mellitus"],"prefix":"10.1002","volume":"69","author":[{"given":"Ilkay","family":"Buran","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Karabuk University Karabuk Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyda","family":"Secgin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Karabuk University Faculty of Medicine  Karabuk Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Ceren","family":"Akal","sequence":"additional","affiliation":[{"name":"Department of Dairy Technology, Ankara University Faculty of Agriculture  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguzhan","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Karab\u00fck University Training and Research Hospital  Karab\u00fck Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Karabuk University Faculty of Medicine  Karabuk Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Karabuk University Faculty of Medicine  Karabuk Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cIDF Diabetes Atlas 11thedition | 08.02.2025 \u201d available athttps:\/\/diabetesatlas.org\/resources\/idf\u2010diabetes\u2010atlas\u20102025."},{"volume-title":"Diabetes Mellitusun Tan\u0131, Tedavi Ve Izlemi","year":"2022","author":"Kocaeli A. 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