{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T14:35:34Z","timestamp":1765550134761,"version":"3.48.0"},"reference-count":51,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity is a growing health concern globally, and current pharmacological interventions often limits efficacy and undesirable side effects, necessitating the search for safer, functional food\u2010based alternatives. This study aims to evaluate the anti\u2010obesity potential of peanut shell extract (PSE), targeting pancreatic lipase enzyme (PLE), altering lipid metabolism. This study employed both in vitro and in vivo approaches. In vitro assays were conducted to assess the inhibitory activity of PSE and its isolated phytochemicals against PLE. In vivo studies involved an SF\u2010induced model, which was administered PSE, and the parameters such as BW, FI, serum lipid profile (LDL, TC, TG), and fecal lipid content were measured to evaluate therapeutic effects. PSE and their isolated phytochemicals showed significant inhibition of PLE activity in vitro with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value ranging from 65.841\u2013251.31\u00a0ng\/mL, when compared to orlistat (49.297\u00a0ng\/mL). In vivo administration of PSE resulted in a significant reduction in the BW, and serum lipid levels, along with a significant increase in fecal lipid excretion compared to control group. PSE exhibits potent anti\u2010obesity effects by inhibiting PLE and modulating lipid absorption and metabolism. These findings support its potential application as a functional food\u2010based therapeutic agent for obesity management.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70325","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T08:37:26Z","timestamp":1763800646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoid\u2010Rich Peanut Shell (\n                    <i>Arachis hypogaea<\/i>\n                    ) Extract as a Functional Food Targeting Pancreatic Lipase to Regulate Lipid Metabolism in Rats"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3565","authenticated-orcid":false,"given":"Rajan","family":"Logesh","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus Bengaluru Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Solanki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology JSS College of Pharmacy, JSS Academy of Higher Education &amp; Research  Mysore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumarappan","family":"Chidambaram","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Pharmacy, King Khalid University Abha Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devesh","family":"Tewari","sequence":"additional","affiliation":[{"name":"Delhi Pharmaceutical Sciences and Research University (DPSRU)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Mehdi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology JSS College of Pharmacy, JSS Academy of Higher Education &amp; Research  Mysore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1270924"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110314"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02750-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00260-0"},{"key":"e_1_2_11_6_1","unstructured":"WHO Obesity and Overweight(World Health Organization 2025) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2022-009773"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2017.08.012"},{"key":"e_1_2_11_9_1","first-page":"27","article-title":"Mescaline Analogs: Substitutions at the 4\u2010Position","volume":"22","author":"Braun U.","year":"1978","journal-title":"NIDA Research Monograph"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.81938"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500001720"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1079\/NRR2006112"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.3.531"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.07.024"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.19163\/2307-9266-2025-13-3-202-238"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.1996.2.323"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.12991\/jrespharm.1661054"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.13.1581"},{"key":"e_1_2_11_19_1","first-page":"195","article-title":"The Historical Development, Efficacy and Safety of Very\u2010Low\u2010Calorie Diets","volume":"5","author":"Howard A. 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