{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:31:06Z","timestamp":1792729866041,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Arsenic exposure from contaminated food and water is a global nutritional issue. Nutritional interventions indicate that dietary polyphenols, such as quercetin, may reduce these toxic effects via antioxidant and immunomodulatory properties. This study examined the protective effect of quercetin against arsenic\u2010induced toxicity in a Wistar rat model. Twenty\u2010four adult Wistar rats were divided into four groups as follows: control (G0), arsenic\u2010exposed (G1; 5\u00a0mg\/kg\/day NaAsO\n                    <jats:sub>2<\/jats:sub>\n                    ), quercetin\u2010treated (G2; approximately 50\u00a0mg\/kg\/day), and co\u2010treated (G3; arsenic + quercetin). Over 28 days, catalase (CAT), glutathione peroxidase (GPx), glutathione S\u2010transferase (GST), superoxide dismutase (SOD), cytokine gene expression (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1, IL\u20104, IL\u201010, TGF\u2010\u03b2), claudin, occludin (CLDN1, OCLN), and fecal microbial profiles (q\u2010PCR, diversity index) were assessed. Our results demonstrate that arsenic exposure significantly reduces antioxidant enzyme levels, elevates pro\u2010inflammatory cytokines, disrupts tight junction protein expression, and causes dysbiosis and proliferation of Proteobacteria and\n                    <jats:italic>E. coli<\/jats:italic>\n                    , ultimately damaging intestinal structure. Quercetin treatment, especially in G3, restored antioxidant levels, balanced cytokine profiles, normalized tight junction gene expression, and maintained gut microbial diversity. Histopathological and correlation analyses also confirmed structural and functional recovery of gut tissues. These findings support quercetin's potential as a dietary intervention to counteract heavy metal\u2013induced gut disorders, reinforcing its nutritional relevance in environmental toxins.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70330","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T12:43:49Z","timestamp":1764852229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quercetin Modulates Gut Microbiome and Immune Response to Mitigate Arsenic\u2010Induced Toxicity: Insights From a Microbiome\u2010Immune Study"],"prefix":"10.1002","volume":"70","author":[{"given":"Areeba","family":"Yaqoob","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Safety School of Public Health Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province Nanjing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian Kamran","family":"Sharif","sequence":"additional","affiliation":[{"name":"Faculty of Food, Nutrition and Home Sciences National Institute of Food Science and Technology University of Agriculture, Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Haider","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences Institute of Physiology and Pharmacology University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Safety School of Public Health Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province Nanjing Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pharmtox\u2010030220\u2010013418"},{"key":"e_1_2_11_3_1","unstructured":"National Institute of Environmental Health Sciences U.S. Department of Health and Human Services \u201cArsenic \u201d (2020) https:\/\/www.niehs.nih.gov\/health\/topics\/agents\/arsenic."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.104539"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007803\u20109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hazl.2023.100090"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"A.Barchowsky L. 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