{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:11Z","timestamp":1790582171138,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study sought to elucidate the potentiality of oil extracted from\n                    <jats:italic>Opisthopterus tardoore<\/jats:italic>\n                    (OT, marine fish available in Bay of Bengal region) on diet induced obesity and explored into the primary molecular process that underlies these effects. Male Swiss albino mice were fed a high\u2010fat diet for 12 weeks to develop obesity, and different doses of OT (200, 400, and 600\u00a0mg\/kg\/day) oil was administered orally for 4 weeks. Following treatment, body weight, biochemical, histological, and genomic parameters were assessed from liver and adipose tissues (ATs). Significant reductions were observed in body weight, lipid profiles, blood glucose, liver, and visceral AT weight, correlated with decreased adipocyte size by supplementation with OT oil. The fish oil significantly upregulates mRNA levels of lipolytic factors such as adiponectin, peroxisome proliferator\u2010activated receptor\u2010\u03b1, carnitine palmitoyl transferase\u20101, lipoprotein lipase, and antiinflammatory cytokines, including interleukin\u20101 receptor antagonist (IL\u20101Ra), IL\u201010, than those of high\u2010fat diet group. Concomitantly, adipogenesis and fatty acid synthesis were arrested by reduction of lipogenic genes, including leptin, fatty acid synthase, sterol regulatory element binding protein\u20101c, and proinflammatory markers (tumor necrosis factor\u2010\u03b1, IL\u20106, inducible nitric oxide synthase, and IL\u20101\u03b2) in adipocytes. The results therefore concluded that OT oil exhibited lipid\u2010lowering along with antiinflammatory properties.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70341","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T10:03:27Z","timestamp":1764583407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antiobesity Efficacy of Marine Tapra Fish (\n                    <i>Opisthopterus tardoore<\/i>\n                    ) Oil in High\u2010Fat Diet\u2010Induced Obese Mice by Activating Lipolysis and Suppressing Adipose Inflammation"],"prefix":"10.1002","volume":"70","author":[{"given":"Pipika","family":"Das","sequence":"first","affiliation":[{"name":"Central Research Laboratory, Department of Paramedical and Allied Health Science Midnapore City College  Midnapore West Bengal India"},{"name":"Biodiversity and Environmental Studies Research Center Midnapore City College 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