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Gut microbiota dysbiosis and impaired intestinal barrier integrity are key factors in NAFLD pathogenesis. Active hexose correlated compound (AHCC), a standardized extract from cultured\n                    <jats:italic>Lentinula edodes mycelia<\/jats:italic>\n                    , has shown immunomodulatory effects, but its impact on gut microbiota and intestinal function in NAFLD remains unclear. This study evaluated AHCC supplementation's effects on gut microbiota composition and intestinal barrier integrity in a high\u2010fat (HF) diet\u2010induced NAFLD rat model. Thirty\u2010two male Sprague\u2010Dawley rats were divided into control diet (CD), HF diet, and HF diet + 2% AHCC groups for 6 weeks. AHCC supplementation significantly altered gut microbiota, increasing alpha diversity and shifting clustering patterns. It increased\n                    <jats:italic>Blautia hansenii<\/jats:italic>\n                    and\n                    <jats:italic>Blautia producta<\/jats:italic>\n                    abundance, known for antiinflammatory and antiobesity properties. These changes correlated with improved intestinal barrier integrity, evidenced by upregulation of Mucin 2 (MUC2) and a trend toward increased tight junction protein expression. AHCC reduced local inflammation in the colon and liver and attenuated systemic inflammation. These findings suggest that AHCC supplementation can modulate gut microbiota composition, thereby mitigating oxidative stress, regulating inflammation, and improving intestinal barrier integrity in HF diet\u2010induced NAFLD.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70345","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T05:48:40Z","timestamp":1764740920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Active Hexose Correlated Compound Modulates Gut Microbiota and Improves Intestinal Barrier Function in a High\u2010Fat Diet\u2010Induced NAFLD in Rats"],"prefix":"10.1002","volume":"70","author":[{"given":"Sungjin","family":"Eun","sequence":"first","affiliation":[{"name":"Division of Food Technology and Nutrition Sun Moon University  Asansi Chungcheongnam\u2010do Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin 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