{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:10Z","timestamp":1790582170058,"version":"4.1.0"},"reference-count":198,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lung cancer remains a leading cause of cancer\u2010related mortality worldwide, with therapeutic resistance and toxicity limiting the effectiveness of conventional treatments. Natural compounds have attracted significant interest as adjuncts to modern oncology owing to their ability to modulate multiple oncogenic pathways with comparatively low toxicity. Among these, genistein (GEN), piperine (PIP), and resveratrol (RES) represent particularly promising candidates. GEN, a phytoestrogen, exerts antiproliferative and pro\u2010apoptotic effects through phosphoinositide 3\u2010kinase\/protein kinase B (PI3K\/Akt), mitogen\u2010activated protein kinase (MAPK), and NF\u2010\u03baB (Nuclear Factor kappa B) signaling. PIP, an alkaloid, not only demonstrates cytotoxicity and cell\u2010cycle arrest but also improves the bioavailability of co\u2010administered therapeutics. RES, a polyphenolic compound, regulates AMP\u2010activated protein kinase (AMPK), PI3K\/Akt, and MAPK pathways, inhibits angiogenesis and metastasis, and sensitizes cancer cells to chemotherapy. Synergistic combinations of these phytochemicals have shown enhanced apoptotic responses and significantly reduced IC\n                    <jats:sub>50<\/jats:sub>\n                    values in cancer, underscoring their potential as multitargeted therapeutic agents. Despite encouraging preclinical and early clinical findings, challenges such as poor solubility and bioavailability hinder clinical translation. This review critically explores their synergistic effects while highlighting the challenges in translating these findings into clinical applications for lung cancer. By elucidating the underlying molecular mechanisms and therapeutic synergy, these natural compounds emerge as promising adjuncts for lung cancer therapy, warranting further mechanistic and clinical investigation.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70348","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T05:54:23Z","timestamp":1764914063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemical Triad in Lung Cancer: Synergistic Mechanisms and Clinical Translation of Genistein, Piperine, and Resveratrol"],"prefix":"10.1002","volume":"70","author":[{"given":"Arpit","family":"Sharma","sequence":"first","affiliation":[{"name":"Biomolecular Engineering Laboratory School of Biochemical Engineering Indian Institute of Technology (IIT\u2010BHU)  Varanasi Uttar Pradesh India"},{"name":"Department of Pharmacology Institute of Medical Science \u2010 Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti S.","family":"Raut","sequence":"additional","affiliation":[{"name":"Biomolecular Engineering Laboratory School of Biochemical Engineering Indian Institute of Technology (IIT\u2010BHU)  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Shukla","sequence":"additional","affiliation":[{"name":"Biomolecular Engineering Laboratory School of Biochemical Engineering Indian Institute of Technology (IIT\u2010BHU)  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Gupta","sequence":"additional","affiliation":[{"name":"Biomolecular Engineering Laboratory School of Biochemical Engineering Indian Institute of Technology (IIT\u2010BHU)  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Medical Science \u2010 Banaras Hindu University  Varanasi Uttar Pradesh India"},{"name":"Baba Kinaram Medical College (BKMC)  Chandauli Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha","family":"Mishra","sequence":"additional","affiliation":[{"name":"Biomolecular Engineering Laboratory School of Biochemical Engineering Indian Institute of Technology (IIT\u2010BHU)  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010023\u201000844\u20100"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-97-6270-5_14"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010020\u201001566\u20100"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seminoncol.2025.152389"},{"key":"e_1_2_15_6_1","first-page":"1","author":"Yan Y.","year":"2024","journal-title":"Nature Genetics"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010025\u201001513\u2010y"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010025\u201011334\u2010z"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010025\u201002726\u20100"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010024\u201002254\u20102"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745\u20107254.2007.00679.x"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02223-9"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201018755\u20103"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201065508\u20100"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.74"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201070309\u20102"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201013842\u20106"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206583"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010023\u201002473\u2010x"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010024\u201000778\u2010y"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201024414\u2010z"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010010\u20109770\u20102"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3365"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010024\u201003725\u20100"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122943"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201050729\u20106"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201065508\u20100"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010013\u20101433\u20104"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450\u2010022\u201000339\u20106"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68574-2"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010024\u201002254\u20102"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004399\u2010z"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.05.001"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033\u2010024\u201001167\u2010w"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201024414\u2010z"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201007006\u20100"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351156"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211666180619125653"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010018\u20100109\u2010y"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102535"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100117"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114514000737"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/767136"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010025\u201003466\u20106"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2015.61"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10375"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.0141"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.71.e122171"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201075059\u2010z"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.35841\/0970\u2010938X.31.5.113\u2010117"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152012803833107"},{"key":"e_1_2_15_52_1","first-page":"2783","article-title":"Role of Resveratrol In Prevention and Therapy of Cancer: Preclinical and Clinical Studies","volume":"24","author":"Aggarwal B. B.","year":"2004","journal-title":"Anticancer Research"},{"key":"e_1_2_15_53_1","first-page":"1","article-title":"Resveratrol Suppresses Lung Cancer by Targeting Cancer Stem\u2010Like Cells and Regulating Tumor Microenvironment","volume":"9","author":"Wang B.","year":"2024","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"e_1_2_15_54_1","first-page":"1","article-title":"Resveratrol Induces Autophagy and Apoptosis in Non\u2010Small\u2010Cell Lung Cancer Cells by Activating the NGFR\u2010AMPK\u2010mTOR Pathway","author":"Rayne S.","year":"2007","journal-title":"Nature Precedings"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201060208\u20101"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.008052"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206583"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2008.08.001"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200900662"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2005.09.005"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.2868"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.10.026"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2024.13169"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2003.12.008"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010146\u201012\u2010200706190\u201000005"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12246"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.02.027"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271\u20105317(01)00331\u20101"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271\u20105317(99)00007\u2010X"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.05.026"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.03.018"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.05.009"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140\u20106736(92)91277\u2010F"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.77"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2015.03.008"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.06.028"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.043"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010006\u20109012\u20100"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70295"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.89942"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1525741"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prenap.2025.100206"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1902"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1516583"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000828\u20105"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210421"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2024.06.007"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14040393"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959\u2010437X(01)00258\u20101"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5341"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955\u20100674(98)80143\u20109"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.3.2.614"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.17.2658"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021870"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M910045199"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010025\u201002950\u20108"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002363\u20101"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2017.1337783"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004434"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2008.07.010"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2024.8766"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010025\u201001310\u2010w"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164\u2010024\u201000529\u2010z"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.09.002"},{"key":"e_1_2_15_105_1","doi-asserted-by":"crossref","unstructured":"N.KanarekandY.Ben\u2010Neriah \u201cn.d. Regulation of NF\u2010\u03baB by ubiquitination and degradation of the I\u03baBs \u201dImmunol. Rev246(2012)77\u201394 https:\/\/doi.org\/10.1111\/j.1600\u2010065X.2012.01098.x.","DOI":"10.1111\/j.1600-065X.2012.01098.x"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.52"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.62347\/YAVK1315"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.31083\/RCM36391"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2024.08.002"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314945"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.6.1705S"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010011\u20101293\u20101"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC330202"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010013\u20101542\u20100"},{"key":"e_1_2_15_115_1","first-page":"7040","article-title":"Genistein Promotes Apoptosis of Lung Cancer Cells Through the IMPDH2\/AKT1 Pathway","volume":"14","author":"Xu H.","year":"2022","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11802"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4817"},{"key":"e_1_2_15_118_1","first-page":"4220","article-title":"ATRA and Genistein Synergistically Inhibit the Metastatic Potential of human Lung Adenocarcinoma Cells","volume":"8","author":"Cheng J.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2404"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010021\u201002091\u20108"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.12.028"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010013\u20101542\u20100"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.12.028"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010024\u201003810\u20102"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30010188"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6260"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202204924"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.05.023"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2022.2076111"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S78988"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112078"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1590\/s2175\u201097902024e22542"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7BM01201B"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300719"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010024\u201002525\u2010z"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.20935\/AcadOnco7881"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2021.07.015"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.05.023"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2022.2118758"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.10.087"},{"key":"e_1_2_15_141_1","first-page":"1106","article-title":"Multicompartimental Nanoparticles for Co\u2010Encapsulation and Multimodal Drug Delivery to Tumor Cells and Neovasculature","volume":"31","author":"Mendes L. P.","year":"2014","journal-title":"Pharmaceutical Research"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.09.019"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35128"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781394270576.ch2"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204252"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122943"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.269"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186532"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722808"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33241"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.2174\/0122103155322306241021043330"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.12.024"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.109211"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14122413"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7747"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102646"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010021\u201003510\u2010z"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.07.124"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668\u2010024\u201001345\u20109"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14715"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431x2024e13537"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201818999210120201252"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.029"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.04.017"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.241817"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm\u20102017\u20100301"},{"key":"e_1_2_15_167_1","unstructured":"C. G.Trotter \u201cThe effects of resveratrol encapsulated nanoparticles on viability of HT\u201029 colon cancer cells \u201dTexas tech university library(2014) http:\/\/hdl.handle.net\/2346\/58538."},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040974"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/app14219658"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2016.08.027"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.07.035"},{"key":"e_1_2_15_172_1","unstructured":"\u201cHome | ClinicalTrials.gov \u201d available athttps:\/\/clinicaltrials.gov\/ n.d. U.S. National Library of Medicine (NLM)."},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010019\u201003886\u20103"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/804510"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202204924"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092709"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010011\u20101879\u20102"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.34172\/apb.2023.023"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.15_suppl.e13556"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061642"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666221004124800"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735417736861"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2021.08.015"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2009.07.001"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.3934\/publichealth.2024038"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7863"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cofs.2015.03.004"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.6235"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.12.2668"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2008.0077"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.0141"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5057"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.573"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100117"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010013\u20109426\u2010y"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.35841\/0970\u2010938X.31.5.113\u2010117"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.71.e122171"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010019\u201000662\u2010w"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejr.2019.08.003"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:13:59Z","timestamp":1790579639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":198,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/mnfr.70348"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70348","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]},"assertion":[{"value":"2025-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70348"}}