{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:11Z","timestamp":1790582171108,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Studies have demonstrated the toxic effects of inevitable exposure of bisphenol A (BPA), especially liver injury via gut\u2010liver axis. Probiotics are increasingly used as adjunctive therapy to ameliorate adversely effects induced by BPA. In view of safety concerns of probiotics, postbiotics are proposed as alternatives to probiotics in clinical applications. At present, no study has directly compared the ameliorative effect of probiotics and postbiotics. This study compares the effect of postbiotics and probiotics derived from\n                    <jats:italic>Lactococcus lactis<\/jats:italic>\n                    NZ9000 employed for BPA\u2010induced liver injury in a mouse model. The results show that both postbiotics and probiotics of\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>lactis<\/jats:italic>\n                    NZ9000 have BPA binding capacity in vitro and in vivo, and administration of probiotics and postbiotics ameliorate BPA\u2010induced liver injury. BPA increases pyroptosis factors and decreases intestinal physical barrier, which reverses by both probiotics and postbiotics treatment. The composition of gut microbiota is also modulated by both probiotics and postbiotics. Notably, the stronger mitigating effects of the above biomarkers are seen in postbiotics treatment than in probiotics treatment. In view of the stronger mitigating effects of postbiotics compared with probiotics and its smaller safety concern, postbiotics are proposed to be considered as next\u2010generation adjunctive therapy to ameliorate adversely effects induced by environmental toxicants.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70356","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T07:30:31Z","timestamp":1766561431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Postbiotics and Probiotics of\n                    <i>Lactococcus lactis<\/i>\n                    NZ9000 in Alleviating Liver Injury Induced by Bisphenol A via Binding and Removing Bisphenol A in Mouse Model"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-3171","authenticated-orcid":false,"given":"Liyang","family":"Yang","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Shanxi University of Chinese Medicine  Jinzhong Shanxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Niu","sequence":"additional","affiliation":[{"name":"Reverse Etiology Research Center Academician Workstation of Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention NHC Key Laboratory of Pneumoconiosis MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Reverse Etiology Research Center Academician Workstation of Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention NHC Key Laboratory of Pneumoconiosis MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushuang","family":"Li","sequence":"additional","affiliation":[{"name":"Reverse Etiology Research Center Academician Workstation of Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention NHC Key Laboratory of Pneumoconiosis MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijing","family":"Kong","sequence":"additional","affiliation":[{"name":"Reverse Etiology Research Center Academician Workstation of Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention NHC Key Laboratory of Pneumoconiosis MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoru","family":"Zhou","sequence":"additional","affiliation":[{"name":"Reverse Etiology Research Center Academician Workstation of Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention NHC Key Laboratory of Pneumoconiosis MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Jing","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jiangsu Food and Pharmaceutical Science College  Huaian PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Guo","sequence":"additional","affiliation":[{"name":"Reverse Etiology Research Center Academician Workstation of Shanxi Medical University, Shanxi Key Laboratory of Environmental Health Impairment and Prevention NHC Key Laboratory of Pneumoconiosis MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University  Taiyuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.10.042"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2013.08.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108575"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.10.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10482\u2010017\u20100846\u20102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.169303"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113582"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010024\u201003882\u20104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70672"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2016.10.039"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010006\u20100632\u2010y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109502"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000440\u20106"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1895061"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12613"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2056727"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14010014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10030519"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00494"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-01343-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010019\u20101716\u20101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000507\u20105"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068\u2010024\u201001564\u20106"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201959"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179314"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.169303"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109182"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114880"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.04.015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.7.3086\u20103091.2001"},{"key":"e_1_2_9_34_1","first-page":"37","article-title":"Efficiency of Multispecies Probiotic Supplements in Bioremoval of Bisphenol A: An In Vitro Study","volume":"5","author":"Solouki S.","year":"2018","journal-title":"Applied Food Biotechnology"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2023.2288533"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11040340"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.108939"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1832857"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194083"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04286.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X25500223"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:14:23Z","timestamp":1790579663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/mnfr.70356"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70356","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70356"}}