{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:11Z","timestamp":1790582171131,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study explored the hepatoprotective effects and underlying mechanisms of tartary buckwheat vinegar (TBV) against alcoholic acute liver injury (AALI). The 60 male ICR mice were divided into six groups: control (Con), model (EtOH, 52\u00b0, Red Star Erguotou, 10\u00a0mL\/kg), metadoxine (Met, 300\u00a0mg\/kg), and TBV low\/medium\/high\u2010dose groups (L\/M\/H, 3.75\/7.5\/12\u00a0mL\/kg). Pharmacological evaluations revealed that ethanol exposure significantly increased the liver index and serum levels of AST and ALT. Moreover, hepatic GSH, SOD, and ALDH enzymatic activity were markedly decreased, while MDA levels and IL\u20101\u03b2 were significantly elevated. Notably, treatment with Met or TBV effectively reversed these changes. Then the underlying mechanisms were elucidated by a strategy combining with gene expression reversal analysis and metabolomics. The results indicated that TBV ameliorates AALI by inhibiting PTGS2, ALOX5, and TRPM8 expression, while simultaneously mitigating extracellular matrix remodeling, lipid metabolic stress, and hepatic edema by downgrading MMP2, FABP3, and AQP1, and enhancing lymphatic drainage through upregulation of LYVE1. Chemical Checker and molecular docking showed that the flavonoids in TBV played a significant role in modulating PTGS2, ALOX5, MMP2, TRPM8, AQP1, LYVE1, FABP3, and ALDH2. In conclusion, TBV might be a potential candidate for functional foods aimed at hepatoprotection against the AALI.<\/jats:p>","DOI":"10.1002\/mnfr.70357","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T07:55:28Z","timestamp":1766562928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gene Expression Reversal and Metabolomics Reveal the Mechanism of Tartary Buckwheat Vinegar Against Alcoholic Acute Liver Injury"],"prefix":"10.1002","volume":"70","author":[{"given":"Bingyao","family":"Dong","sequence":"first","affiliation":[{"name":"Modern Research Center For Traditional Chinese Medicine Shanxi University  Taiyuan Shanxi People's Republic of China"},{"name":"The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi People's Republic of China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Kong","sequence":"additional","affiliation":[{"name":"Modern Research Center For Traditional Chinese Medicine Shanxi University  Taiyuan Shanxi People's Republic of China"},{"name":"The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi People's Republic of China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[{"name":"Modern Research Center For Traditional Chinese Medicine Shanxi University  Taiyuan Shanxi People's Republic of China"},{"name":"The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi People's Republic of China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Nie","sequence":"additional","affiliation":[{"name":"Modern Research Center For Traditional Chinese Medicine Shanxi University  Taiyuan Shanxi People's Republic of China"},{"name":"The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi People's Republic of China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[{"name":"Modern Research Center For Traditional Chinese Medicine Shanxi University  Taiyuan Shanxi People's Republic of China"},{"name":"The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi People's Republic of China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.02.050"},{"key":"e_1_2_9_3_1","first-page":"70","article-title":"Tartary Buckwheat Extract Alleviates Alcohol\u2010Induced Acute and Chronic Liver Injuries Through the Inhibition of Oxidative Stress and Mitochondrial Cell Death Pathway","volume":"12","author":"Yang Q.","year":"2020","journal-title":"American Journal of Translational 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