{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:36:28Z","timestamp":1785368188030,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["16485 NutrI2FIT: Strengthening Immune Fi"],"award-info":[{"award-number":["16485 NutrI2FIT: Strengthening Immune Fi"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Several studies demonstrated curative responses of combined radio\u2010immunotherapy, although not standard\u2010of\u2010care for most cancers. Increased fiber intake has been associated with improved radiotherapy and immunotherapy outcomes, but fiber compositions\u2019 impact remains unclear. This study aimed to explore whether dietary fiber composition influences the therapeutic outcome of combined radio\u2010immunotherapy in a preclinical cancer model. A syngeneic mouse model of colon cancer (CT26) (female BALB\/cOla Hsd) was used. Mice were randomized into three groups (\n                    <jats:italic>n<\/jats:italic>\n                    = 12) of iso\u2010caloric diets with different fiber compositions. Five instances of local radiotherapy on tumors, combined with injections of anti\u2010PD\u2010L1, were administered over 5 and 10 days. Diets\u2019 impact was assessed on progression\u2010free survival, SCFA levels in fecal and cecal samples, gut microbiome composition, and immunological profile. Progression\u2010free survival was different between compositions, as well as their gut microbiota community structure, at all measured time\u2010points. Therapeutic outcome (cure) was negatively associated with the relative abundance of\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    and positively with\n                    <jats:italic>Atopobiaceae Family<\/jats:italic>\n                    . There was no association with SCFA levels. Cured mice displayed smaller spleens containing increased proportions of CD8+ T\u2010cells and decreased proportions of myeloid\u2010derived suppressor cells. Our data suggest that fiber composition may influence therapeutic outcome of combined radio\u2010immunotherapy treatment in vivo.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70370","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:05:32Z","timestamp":1768975532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Dietary Fiber Compositions on the Therapeutic Outcome of Combined Radio\u2010 and Immunotherapy in a Preclinical Cancer Model"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8237-3715","authenticated-orcid":false,"given":"Annemarie J. F.","family":"Westheim","sequence":"first","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"},{"name":"Department of Genetics and Cell Biology, NUTRIM\u2010Research Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig J.","family":"Dubois","sequence":"additional","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Prades\u2010Sagarra","sequence":"additional","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Infectious Diseases and Infection Prevention, NUTRIM\u2010Research Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M. A.","family":"van der Wiel","sequence":"additional","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja G.","family":"Lieuwes","sequence":"additional","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Biemans","sequence":"additional","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cong","sequence":"additional","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Houben","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, NUTRIM\u2010Research Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis M.","family":"Meesters","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, NUTRIM\u2010Research Institute of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Yaromina","sequence":"additional","affiliation":[{"name":"The M\u2010Lab, Department of Precision Medicine, GROW\u2010Research Institute for Oncology and Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van Bergenhenegouwen","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardy","family":"van Helvoort","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht the Netherlands"},{"name":"Department of Respiratory Medicine, NUTRIM\u2010Research Institute of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon C. 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