{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:04Z","timestamp":1790582164461,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the protective effects of\u00a0\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    \u00a0NXU0014 against chronic alcoholic liver injury (CALI) and its underlying mechanisms in a mouse model. Forty\u2010eight male C57BL\/6J mice were divided into four groups: blank control, model, silymarin, and\u00a0\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    \u00a0NXU0014. The CALI model was induced by administering 56% Hongxing Erguotou liquor. Multi\u2010omics analyses revealed that alcohol intake induced gut microbiota dysbiosis, characterized by an increased Firmicutes\/Bacteroidetes ratio and decreased abundance of probiotics (e.g.,\u00a0Lactobacillus\u00a0and\u00a0Bifidobacterium). These changes were associated with hepatic pro\u2010inflammatory upregulation, downregulation of antioxidant genes (Nrf2, HO\u20101), and impaired intestinal barrier function (ZO\u20101). Metabolomic disturbances featured elevated fecal bile acids, reduced amino acids, and enriched pathways for ABC transporters and bile secretion. Intervention with NXU0014 restored probiotic levels (including\n                    <jats:italic>Bifidobacterium pseudodanubicum<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus reuteri<\/jats:italic>\n                    ), alleviated hepatic inflammation and oxidative stress by activating the Nrf2\/HO\u20101 pathway, and repaired the intestinal barrier. Integrated microbiome\u2010metabolome analysis revealed a negative correlation between\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and toxic bile acids, and a positive correlation between\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    and anti\u2010inflammatory metabolites. These findings demonstrate that NXU0014 mitigates liver injury by modulating gut\u2010liver axis metabolic interactions, highlighting its potential as a novel probiotic\u2010based therapy for alcoholic liver disease.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70375","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:31:13Z","timestamp":1768573873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Mechanisms of\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    NXU0014 Against Chronic Alcohol\u2010Induced Liver Injury Mediated by Gut\u2010Liver Axis Modulation"],"prefix":"10.1002","volume":"70","author":[{"given":"Quan","family":"Ji","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Ningxia University Ningxia Key Laboratory of Food and Biomanufacturing  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningxia University Ningxia Key Laboratory of Food and Biomanufacturing  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxuan","family":"Huo","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningxia University Ningxia Key Laboratory of Food and Biomanufacturing  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qiao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningxia University Ningxia Key Laboratory of Food and Biomanufacturing  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningxia University Ningxia Key Laboratory of Food and Biomanufacturing  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningxia University Ningxia Key Laboratory of Food and Biomanufacturing  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningxia University Ningxia Key Laboratory of Food and Biomanufacturing  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914809"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0145"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30752\u20102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.026"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.70019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010022\u201010438\u20100"},{"key":"e_1_2_9_10_1","unstructured":"H.Lu G.Zhang K.Wang et\u00a0al. \u201cThe Role ofLactiplantibacillus plantarumCGMCC9513 in Alleviating Colitis by Synergistic 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