{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:05Z","timestamp":1790582165263,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K11584"],"award-info":[{"award-number":["21K11584"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    2\n                    <jats:bold>\u2032<\/jats:bold>\n                    \u2010Fucosyllactose (2\u2032FL) is an abundant human milk oligosaccharide and is recognized for its diverse biological benefits. The aim of this study was to investigate the effects of 2\u2032FL supplementation on small intestinal remodeling and the associated enhancement of nutrient absorption capabilities. Mice were orally supplemented with 2\u2032FL daily for 20 d. This supplementation significantly increased the length of the small intestine and the density of villi, with no adverse effects on intestinal barrier function. Mice treated with 2\u2032FL exhibited an enhanced absorption of triglycerides containing docosahexaenoic acid in lipid tolerance tests. Additionally, the absorption of CL316,243 and curcumin was significantly increased in the co\u2010administration groups. This was accompanied by elevated uncoupling protein 1 levels in inguinal adipose tissue. Our study showed that 2\u2032FL enhances nutrient and functional compound absorption by promoting intestinal remodeling. This highlights the novel role of 2\u2032FL\u2014a non\u2010nutritive compound\u2014in supporting intestinal health. Our findings suggest potential applications of 2\u2032FL in growth promotion, lifestyle\u2010related disease prevention, and frailty reduction, thereby advancing research on the nutritional functions of food\u2010derived compounds.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70376","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:19:16Z","timestamp":1768573156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two\u2032\u2010Fucosyllactose, a Human Milk Oligosaccharide, Promotes Intestinal Remodeling and Enhances Nutrient and Functional Component Absorption"],"prefix":"10.1002","volume":"70","author":[{"given":"Sho","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Funasaki","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakana","family":"Jike","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Taromaru","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izuki","family":"Tarushima","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoto","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuki","family":"Nishimaki","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanami","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Okuzawa","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimu","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences Teikyo University of Science  Uenohara\u2010shi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2019.22.4.330"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadva.2024.100136"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cws074"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819f1e05"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010071813\u2010105721"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.230706"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207744200"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.5.1304"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516002944"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.189704"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01773"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003827\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.65.328"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700731"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000709"},{"key":"e_1_2_9_17_1","first-page":"1326","article-title":"Docosahexaenoic Acid in Formulas for Term Infants: The Way From Pioneer Idea to Mandatory Dietary Recommendation","volume":"13","author":"Decsi T.","year":"2023","journal-title":"Life (Basel)"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2022.02.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01242J"},{"key":"e_1_2_9_20_1","first-page":"11","article-title":"Development of Beta 3\u2010Adrenoceptor Agonists for the Treatment of Obesity and Diabetes\u2013an Update","volume":"25","author":"Weyer C.","year":"1999","journal-title":"Diabetes & Metabolism"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100735"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1592683"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8020099"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0710480"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9044205"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.248138"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.2005.02356.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.010033"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47080637"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010025\u201002112\u20106"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2024.171210"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2019.1677144"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b06647"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2024.103337"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.11.017"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14343"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:13:24Z","timestamp":1790579604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/mnfr.70376"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70376","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70376"}}