{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:56:03Z","timestamp":1790582163500,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tryptophan (TRP) metabolism is emerging as a focus of investigation in Alzheimer's disease research. In addition, diet might impact TRP's metabolic fate. The aim of this study was to explore the association between adherence to the Dutch Mediterranean\u2010Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND\u2010NL) diet and systemic TRP metabolite levels and their related ratios in older adults at risk of cognitive decline. Data of the HELI multidomain lifestyle intervention study (\n                    <jats:italic>n<\/jats:italic>\n                    = 82) were used. Dietary intake data (FFQ) and fasted plasma levels were collected at baseline and 26 weeks follow\u2010up. Bivariate Latent Change Score Models (LCSMs) were applied to assess both level\u2010level and change\u2010change associations, adjusted for lifestyle factors. Changes in MIND\u2010NL diet adherence were significantly inversely associated with changes in the kynurenine:large neutral amino acids ratio (path coefficient \u22120.457, SE:0.206,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03) and kynurenine:tryptophan ratio (path coefficient \u22120.558 SE:0.235,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02). In addition, MIND\u2010NL diet adherence was associated with lower levels of the neurotoxic metabolite quinolinic acid (path coefficient \u22120.186, SE:0.0700,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.008), but within the crude model only. Our findings suggest that greater adherence to the MIND\u2010NL diet may contribute to decreased activation of the kynurenine pathway.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70377","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:46:38Z","timestamp":1768574798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between the Dutch Mediterranean\u2010Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND\u2010NL) Diet Adherence and Systemic Tryptophan Metabolites in Older Adults at Risk of Cognitive Decline: An Exploratory Study"],"prefix":"10.1002","volume":"70","author":[{"given":"Sonja","family":"Beers","sequence":"first","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette C. P. G. M.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"van Loenen","sequence":"additional","affiliation":[{"name":"Radboud University Donders Institute for Brain, Cognition and Behaviour  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne B.","family":"Remie","sequence":"additional","affiliation":[{"name":"Radboud University Donders Institute for Brain, Cognition and Behaviour  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mechteld Grootte","family":"Bromhaar","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Anesi","sequence":"additional","affiliation":[{"name":"Unit of Metabolomics, Department of Food Quality and Nutrition Research and Innovation Centre, Fondazione Edmund Mach (FEM)  San Michele all'Adige Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urska","family":"Vrhovsek","sequence":"additional","affiliation":[{"name":"Unit of Metabolomics, Department of Food Quality and Nutrition Research and Innovation Centre, Fondazione Edmund Mach (FEM)  San Michele all'Adige Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joukje M.","family":"Oosterman","sequence":"additional","affiliation":[{"name":"Radboud University Donders Institute for Brain, Cognition and Behaviour  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Aarts","sequence":"additional","affiliation":[{"name":"Radboud University Donders Institute for Brain, Cognition and Behaviour  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara P. H.","family":"van Trijp","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Vermeiren","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70223\u20104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29215131"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010023\u20102046\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104556"},{"key":"e_1_2_10_7_1","first-page":"165","volume-title":"Comprehensive Metabolism","author":"Comai S.","year":"2020"},{"key":"e_1_2_10_8_1","article-title":"Dynamic Changes in Kynurenine Pathway Metabolites in Multiple Sclerosis: A Systematic Review","volume":"13","author":"Fathi M.","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10039\u2010010\u20100023\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-019-00208-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010022\u201003546\u20108"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101800"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0752-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14843"},{"key":"e_1_2_10_16_1","first-page":"3","article-title":"Overview of the Role of Vitamins and Minerals on the Kynurenine Pathway in Health and Disease","volume":"67","author":"Majewski M.","year":"2016","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab238"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201068522\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306\u2010024\u201002184\u20101"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300329"},{"key":"e_1_2_10_21_1","article-title":"The MIND Diet for the Ageing Brain: A Systematic Review","volume":"15","author":"Soest A. P. M.","year":"2024","journal-title":"Advances in Nutrition"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2196\/69814"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.06.005"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114524001892"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00946"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895\u20104356(03)00220\u20108"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101781(89)90047\u20104"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anr.2012.08.004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14573"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705519909540118"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.17536.1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112237"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.10.003"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010021\u201005521\u20104"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220295"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm6131"},{"key":"e_1_2_10_37_1","article-title":"Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease","author":"Liang Y.","year":"2022","journal-title":"Disease Markers"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.11.004"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.04.015"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.093020"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178646920938688"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178646920970902"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:12:43Z","timestamp":1790579563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/mnfr.70377"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70377","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70377"}}