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However, the in vivo effects remain unclear. Therefore, using a high\u2010fat diet\/streptozotocin\u2010induced T2DM mouse model to assess the metabolic impact of S\u2010A, the results showed that dietary supplementation with S\u2010A regulated glucose\u2010lipid homeostasis, significantly reducing serum total cholesterol (5.98 \u00b1 1.02\u21923.21 \u00b1 1.07\u00a0mmol\/L) and low\u2010density lipoprotein cholesterol (3.25 \u00b1 0.67\u21921.15 \u00b1 0.74\u00a0mmol\/L), with histopathological analysis revealing alleviated hepatic steatosis, renal fibrosis, and adipocyte hypertrophy; moreover, S\u2010A reshaped the gut microbiota by enriching beneficial taxa, suppressing pathogens, and elevating short\u2010chain fatty acids, while predictive functional analysis indicated restoration of microbial pathways involved in energy and amino acid metabolism. Overall, S\u2010A exerts multifaceted regulation of lipid\u2010glucose metabolism and gut microbiota, mitigating metabolic dysfunction in diabetic mice, and these findings underscore its potential as a novel functional dietary intervention while promoting the value\u2010added utilization of purple red rice bran in managing metabolic disorders.<\/jats:p>","DOI":"10.1002\/mnfr.70384","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:17:59Z","timestamp":1768573079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rice Starch\u2013Purple Red Rice Bran Anthocyanins Complex Improves Glucose\u2013Lipid Homeostasis and Restores Gut Microbiota in High\u2010Fat Diet\/Streptozotocin\u2010Induced Type 2 Diabetic Mice"],"prefix":"10.1002","volume":"70","author":[{"given":"Weidong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and 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