{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:18:09Z","timestamp":1772983089781,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The intestinal bone morphogenetic protein (BMP) pathway counteracts the Wnt pathway, which is overactivated in 90% of colorectal cancers (CRC) due to mutations in the\n                    <jats:italic>adenomatous polyposis coli<\/jats:italic>\n                    (\n                    <jats:italic>APC)<\/jats:italic>\n                    gene. Our study aimed to identify a polyphenol that acts on the colonic BMP pathway and to evaluate its ability to mitigate the harmful effects of 4\u2010hydroxynonenal (HNE), a dietary genotoxic molecule, on normal colonocytes. We first evaluated the effect of 10 polyphenols on the expression of BMP pathway actors using a normal mouse colonocyte and fibroblast culture model. Apigenin (Apig) and resveratrol (Res) increased the production of BMP4 ligand and reduced expression of the\n                    <jats:italic>Gremlin1 (Grem1)<\/jats:italic>\n                    antagonist in fibroblasts. Apig also enhanced the expression of the\n                    <jats:italic>bone morphogenetic protein receptor type 2<\/jats:italic>\n                    (\n                    <jats:italic>Bmpr2)<\/jats:italic>\n                    in fibroblasts and that of the\n                    <jats:italic>Smad1<\/jats:italic>\n                    effector in colonocytes. Finally, Apig inhibited the phenotypic transformation of colonocytes induced by HNE through a mechanism that involved the BMP pathway in both fibroblasts and colonocytes. Our findings suggest that targeting the colonic BMP signaling pathway through dietary factors could contribute to the prevention of CRC. Apig\u2010rich foods or supplements may play a role in this preventive nutrition, although further in vivo experiments are needed to confirm this potential.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70387","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:45:31Z","timestamp":1769492731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyphenols as Modulators of the BMP Signaling Pathway to Counter Phenotypic Transformation of Colonocytes"],"prefix":"10.1002","volume":"70","author":[{"given":"Emma","family":"Cogo","sequence":"first","affiliation":[{"name":"National Research Institute for Agriculture and Environment (INRAE) Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP\u2010Purpan UPS, Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Fouch\u00e9","sequence":"additional","affiliation":[{"name":"National Research Institute for Agriculture and Environment (INRAE) Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP\u2010Purpan UPS, Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Dupuy","sequence":"additional","affiliation":[{"name":"National Research Institute for Agriculture and Environment (INRAE) Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP\u2010Purpan UPS, Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Pierre","sequence":"additional","affiliation":[{"name":"National Research Institute for Agriculture and Environment (INRAE) Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP\u2010Purpan UPS, Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Gu\u00e9raud","sequence":"additional","affiliation":[{"name":"National Research Institute for Agriculture and Environment (INRAE) Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP\u2010Purpan UPS, Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Plaisanci\u00e9","sequence":"additional","affiliation":[{"name":"National Research Institute for Agriculture and Environment (INRAE) Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP\u2010Purpan UPS, Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006640\u2010x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.07.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13824"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.03.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1477\u20103163.78111"},{"key":"e_1_2_11_7_1","first-page":"1367","article-title":"Bone Morphogenetic Proteins Development and Clinical Efficacy in the Treatment of Fractures and Bone Defects","volume":"87","author":"Termaat M. 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