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This study evaluated the therapeutic potential of lycopene in attenuating obesity\u2010induced cardiac remodeling, based on its antioxidant and anti\u2010inflammatory properties and its ability to inhibit matrix metalloproteinase\u20102 (MMP\u20102) activation, thereby preserving myocardial collagen integrity. Male Wistar rats were fed a high\u2010sugar, high\u2010fat (HSF) diet to induce obesity and cardiac remodeling. After the onset of cardiac dysfunction, animals received lycopene supplementation (10 mg\/kg\/day) for 10 weeks. The HSF diet caused metabolic disturbances, including hypertension, increased adiposity, and insulin resistance, accompanied by myocardial remodeling, inflammation, and elevated MMP\u20102 activity. Lycopene supplementation reversed insulin resistance, mitigated myocardial remodeling, and improved both systolic and diastolic cardiac function. It also reduced inflammatory markers (TNF\u2010\u03b1, IL\u20106, NF\u2010\u03baB, TLR\u20104), decreased MMP\u20102 activation, and enhanced TIMP\u20102 and type I collagen expression. Lycopene demonstrated cardioprotective and anti\u2010inflammatory effects in obesity\u2010induced cardiac remodeling. By targeting inflammation and extracellular matrix degradation, lycopene may serve as an effective adjunctive therapeutic approach for preventing or treating obesity\u2010related cardiac disorders.<\/jats:p>","DOI":"10.1002\/mnfr.70395","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:51:12Z","timestamp":1769493072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lycopene's Role in Mitigating Obesity\u2010Induced Cardiac Remodeling: Insights Into Inflammatory and MMP\u20102 Pathways"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9911-6254","authenticated-orcid":false,"given":"Carol Cristina Vagula de Almeida","family":"de Silva","sequence":"first","affiliation":[{"name":"Medical School Sao Paulo State University (UNESP)  Botucatu Brazil"},{"name":"Instituto de Estudos do Mar Almirante Paulo Moreira Marine Biotechnology Department 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