{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:01Z","timestamp":1786978201756,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study investigated the potential beneficial effect of probiotic\n                    <jats:italic>Lacticaseibacillus paracasei DG I1572 (L. paracasei DG I1572)<\/jats:italic>\n                    in a murine model of vascular inflammaging. Aged (40\u2010weeks\u2010old) and young (10\u2010weeks\u2010old) Sprague\u2010Dawley rats were treated with\n                    <jats:italic>L. paracasei DG I1572<\/jats:italic>\n                    for 3 months. Vascular functions were assessed by pressurized myography, while intravascular ROS and NO production, as well as inflammatory parameters (IL\u20101\u03b2, IL\u20106, IL\u201010, and TNF), were measured using dihydroethidium, 4\u2010amino\u20105\u2010methylamino\u20102\u2032,7\u2032\u2010difluorofluorescein dyes, and ELISA, respectively. Malondialdehyde (MDA) and claudin\u20101 were examined. Old rats showed: (1) vascular endothelial dysfunctions due to a reduced NO availability; (2) increase in intravascular ROS, (3) the presence of systemic inflammation and oxidative stress, as documented by increased plasma levels of IL\u20106 and MDA, respectively; (4) a slight decrease in claudin\u20101 colonic expression, as compared with young rats. Treatment with\n                    <jats:italic>L. paracasei DG I1572<\/jats:italic>\n                    in old rats improved: (1) endothelial function, increasing NO bioavailability; (2) systemic and in situ oxidative stress in vessels, reducing MDA and intravascular ROS production, respectively; (3) inflammatory parameters, reducing IL\u20101\u03b2 and IL\u20106 as well as increasing IL\u201010; (4) colonic expression of claudin\u20101.\n                    <jats:italic>L. paracasei DG I1572<\/jats:italic>\n                    supplementation can mitigate the low\u2010grade inflammation, and the vascular dysfunctions associated with age, likely through antioxidant and anti\u2010inflammatory properties.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70399","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T04:50:43Z","timestamp":1770007843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gut Microbiota Manipulation by Probiotic\n                    <i>Lacticaseibacillus paracasei DG I1572<\/i>\n                    as New Therapeutical Strategy to Counteract Vascular Inflammaging"],"prefix":"10.1002","volume":"70","author":[{"given":"Vanessa","family":"D'Antongiovanni","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7083-4214","authenticated-orcid":false,"given":"Clelia Di","family":"Salvo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Valdiserra","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fornai","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Mengozzi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Virdis","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Masi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Duranti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-5053","authenticated-orcid":false,"given":"Laura","family":"Benvenuti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Fiore","sequence":"additional","affiliation":[{"name":"Corporate R&amp;D, Alfasigma S.p.A., Trezzano Rosa Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"De Vitis","sequence":"additional","affiliation":[{"name":"Corporate R&amp;D, Alfasigma S.p.A., Trezzano Rosa Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Antonioli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXGER.2017.12.015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2017.01960"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS10112974"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2012.5148"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS11061010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1474\u20109726.2011.00783.X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12979\u2010020\u201000213\u2010W"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CHOM.2017.03.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/S40168\u2010022\u201001243\u2010W"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617736478"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616684398"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/FRAGI.2021.727604\/PDF"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872\u2010200301000\u201000029"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/PRP2.871"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2018.01094"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320888"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHV365"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.16200"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/MNFR.202200442"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/METABO13030410"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/APHA.14232"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO90116A"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCVM.2021.752305"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41569\u2010018\u20100064\u20102"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2022.882211"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41435\u2010021\u201000126\u20108"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ACEL.13279"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXGER.2021.111517"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41569\u2010018\u20100030\u2010Z"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.0617"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS18122563"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02702\u201016"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCM11071916"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617736478"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1801944"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00394\u2010021\u201002680\u20103"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/DMM.049969"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/GLT106"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/NU14050949"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00612.2020"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/FMICB.2021.706135"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2020.07.067"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616684398"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/S11658\u2010024\u201000603\u20108"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220904"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220904"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/S11658\u2010024\u201000603\u20108"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00726\u2010022\u201003161\u20105"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24010724"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70399","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:20:08Z","timestamp":1781540408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/mnfr.70399"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70399","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70399"}}