{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:48:39Z","timestamp":1773373719778,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hulless barley grass (HBG) is rich in bioactive compounds such as phenolics, polysaccharides, and lipids, and consequently possesses antioxidant, anti\u2010inflammatory, and anti\u2010tumor properties. However, which components contribute to its potential palliative effect on acute ulcerative colitis (AUC) is unknown. In this study, phenolics, polysaccharides, and lipids were extracted separately from HBG, and their antioxidant activities and effects on AUC in vivo were investigated. Compared to the polysaccharide\/lipid extracts, phenolic extracts (HBGPE) had much higher antioxidant capacity, with 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl radical (DPPH\u00b7) scavenging capacity of 1.34 \u00b1 0.02\u00a0mmol Trolox\/100 g. The HBGPE also significantly decreased the body weight loss and colonic condition of dextran sodium sulfate (DSS)\u2010induced AUC mice. The strong anti\u2010inflammatory effects of HBGPE led to a significant reduction in the degree of inflammatory cell infiltration, crypt structure disruption, and mucosal damage, and down\u2010regulated the mRNA expression of tumor necrosis factor (\n                    <jats:italic>Tnf\u03b1<\/jats:italic>\n                    ), interleukin\u20106 (\n                    <jats:italic>Il6<\/jats:italic>\n                    ), and\n                    <jats:italic>Il1b<\/jats:italic>\n                    . In addition, HBGPE could reduce intestinal flora disorders. Both polysaccharide and lipid extracts led to little reduction in the colon inflammatory condition. This study confirmed that HBG extracts could inhibit inflammatory response, oxidative stress, and gut microbial imbalance, especially HBGPE, which indicated that HBG may have potential for application in dietary prevention of AUC.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70401","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:29:18Z","timestamp":1772998158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Palliative Effects of Phenolic, Polysaccharide, and Lipid Extracts of Hulless Barley Grass on Acute Ulcerative Colitis"],"prefix":"10.1002","volume":"70","author":[{"given":"Zhiqian","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Food Science &amp; Technology, School of Agriculture and Biology Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology, School of Agriculture and Biology Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology, School of Agriculture and Biology Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Corke","sequence":"additional","affiliation":[{"name":"Institute of Agro\u2010Product Processing Jiangsu Academy of Agricultural Sciences  Nanjing PR China"},{"name":"Faculty of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Engineering Guangdong Technion\u2010Israel Institute of Technology  Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongquan","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology, School of Agriculture and Biology Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00003-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.186"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46693"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2023.115251"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c04576"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X15500743"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183833"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3232080"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01028-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.16798"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127655"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.113860"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.11.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400568"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3334994"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04756-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63465-y"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau6085"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13357"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2022020189"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132057"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.11.015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2022.09.002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-239-1_19"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.173753"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080669"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i18.2733"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12185956"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.12.070"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061571"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168431"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040726"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i1.5"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.06.011"}],"container-title":["Molecular Nutrition &amp; 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