{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:11:52Z","timestamp":1773018712092,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Spinal cord injury (SCI) results in rapid bone loss and osteoporosis development. This study investigated the synergistic effects of a combination of thymoquinone (TQ) and coenzyme Q10 (CoQ10) on SCI\u2010induced osteoporosis. Thirty male Wistar rats underwent complete spinal cord transection at T10 and were divided into five groups: sham, untreated SCI, TQ\u2010treated (100\u00a0mg\/kg\/day), CoQ10\u2010treated (10\u00a0mg\/kg\/day), and combination therapy (TQ + CoQ10). After 21 days of treatment, combination therapy significantly improved BBB locomotor scores (12.1\u00a0\u00b1\u00a00.7\u00a0vs. 2.1\u00b10.4 in untreated SCI;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and increased femoral BMD and BMC by 32.8% and 37.9%, respectively. Micro\u2010CT analysis revealed 45.2% higher bone volume\/total volume ratio and enhanced trabecular architecture. The combination therapy significantly downregulated SOST expression (76.2% reduction) while upregulating periostin (184.7% increase). Osteoclast markers decreased (CTR: 57.3%, cathepsin K: 63.1%) while osteoblast markers increased (ALP: 143.8%, osterix: 127.4%). Oxidative stress markers improved substantially, with 47.3% lower MDA levels and 86.5% higher SOD activity. TQ + CoQ10 combination therapy produces both synergistic and additive effects that ameliorates SCI\u2010induced osteoporosis in association with altered expression of Wnt\/\u03b2\u2010catenin signaling components, enhancing bone formation, and reducing oxidative stress, demonstrating superior therapeutic efficacy compared to monotherapies.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70402","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:41:55Z","timestamp":1773002515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thymoquinone\u2010Coenzyme Q10 Combination Therapy Ameliorates Post\u2010Spinal Cord Injury Osteoporosis Through Enhanced Wnt\/\u03b2\u2010Catenin Signaling and Antioxidant Defense"],"prefix":"10.1002","volume":"70","author":[{"given":"JiZu","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Zhuzhou Central Hospital  Zhuzhou Hunan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Zhuzhou Central Hospital  Zhuzhou Hunan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Neurology Zhuzhou Central Hospital  Hunan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Neurology Zhuzhou Central Hospital  Hunan Province 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