{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:07:44Z","timestamp":1792030064042,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Allium mongolicum<\/jats:italic>\n                    \u00a0Regel (AMR), a traditional edible and medicinal herb widely consumed in Asian cuisines, presents an important but understudied food safety concern due to its allergenic potential. This study bridges the gap between food science and health impacts by characterizing the first major allergen in AMR. Through an integrated approach combining transcriptome sequencing and immunological techniques, we identified glyceraldehyde\u20103\u2010phosphate dehydrogenase (GAPDH) as a novel food allergen. The recombinant GAPDH protein exhibited clinically relevant IgE reactivity in 48.1% (13\/27) of allergic individuals' sera, establishing its role in food allergy. Notably, we demonstrated that this food\u2010derived allergen triggers distinct inflammatory pathways in human gastrointestinal (Caco\u20102) and respiratory (BEAS\u20102B) epithelial cells\u2014key interfaces for food\u2010host interactions. Transcriptomic analysis revealed tissue\u2010specific responses: intestinal cells upregulated immunemodulatory genes (EPHB1, CD226, CD59), while lung cells activated interferon signaling, offering theoretical explanations for how dietary components may influence mucosal immunity. These findings significantly advance our understanding of herbal food allergies and pave the way for developing safer functional foods and targeted allergy management strategies.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70405","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:36:03Z","timestamp":1770363363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of GAPDH as an Allergen in\n                    <i>Allium Mongolicum<\/i>\n                    Regel and Its Pro\u2010Inflammatory Effects on respiratory and Intestinal Epithelia"],"prefix":"10.1002","volume":"70","author":[{"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"Dermatology Department Beijing Shijitan hospital Capital Medical university  Beijing 100038 China"},{"name":"Allergy Center Beijing Shijitan Hospital Capital Medical University  Beijing 100038 China"},{"name":"Beijing Laboratory of Allergic Diseases Beijing Municipal Education Commission  Beijing 100038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi 214023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Research Center The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi 214023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfen","family":"Liao","sequence":"additional","affiliation":[{"name":"Clinical Research Center The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi 214023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Research Center The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi 214023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Gong","sequence":"additional","affiliation":[{"name":"Clinical Research Center The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi 214023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Clinical Research Center The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi 214023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Allergy Center Beijing Shijitan Hospital Capital Medical University  Beijing 100038 China"},{"name":"Beijing Laboratory of Allergic Diseases Beijing Municipal Education Commission  Beijing 100038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubao","family":"Cui","sequence":"additional","affiliation":[{"name":"Clinical Research Center The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi 214023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20191206-01"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041474"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.06.005"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"689","article-title":"Garlic and Onion Sensitization among Saudi Patients Screened for Food Allergy: A Hospital Based Study","volume":"13","author":"Almogren A.","year":"2013","journal-title":"African Health Sciences"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00460.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2022.43.210112"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.926"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.993893"},{"issue":"11","key":"e_1_2_11_10_1","first-page":"512","article-title":"Changes of Leaf's Carbohydrate and Protein Content during Growth and Development of Allium Mongolicum Regel","volume":"47","author":"Shimin T. 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