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Eugenol (EUG), a natural compound with antioxidative and anti\u2010inflammatory properties, was investigated for its protective effects against Dityr\u2010induced hepatotoxicity in this work. In this study, in vivo and in vitro analyses demonstrated EUG's protective effects against Dityr\u2010induced hepatotoxicity. EUG significantly attenuated oxidative stress markers, inflammatory infiltration, fibrotic progression, and apoptotic signaling in mice liver tissues. Mechanistically, EUG activated the Akt\/NF\u2010E2\u2010related factor 2\/antioxidant response element (Akt\/Nrf2\/ARE) pathway, enhancing cellular antioxidant capacity while suppressing pro\u2010inflammatory cytokine release. In HepG2 cells, EUG treatment effectively counteracted Dityr\u2010induced ROS overproduction and cell death through Nrf2\u2010mediated antioxidant upregulation. In conclusion, our findings indicate that EUG effectively mitigates Dityr\u2010induced oxidative stress via the Akt\/Nrf2\/ARE pathway, and this antioxidative impact further inhibits inflammation and apoptosis. These effects ultimately ameliorate liver function impairment caused by Dityr.<\/jats:p>","DOI":"10.1002\/mnfr.70412","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:35:08Z","timestamp":1773322508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eugenol\u2010Derived Cytoprotective Action Against Dityrosine\u2010Induced Oxidative Stress in Mice Liver via Akt\/Nrf2\/ARE Signaling Pathway"],"prefix":"10.1002","volume":"70","author":[{"given":"Yin\u2010Yi","family":"Ding","sequence":"first","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety, School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou China"},{"name":"Panvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital  Quzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety, School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchi","family":"Lan","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety, School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety, School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety, School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Gu","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety, School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&amp;D of Chinese Medicine Anhui University of Chinese Medicine  Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9921-6363","authenticated-orcid":false,"given":"Yujun","family":"Ge","sequence":"additional","affiliation":[{"name":"Jiaxing Central Blood Station  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-0182","authenticated-orcid":false,"given":"Qing","family":"Shen","sequence":"additional","affiliation":[{"name":"Panvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital  Quzhou China"},{"name":"Laboratory of Food Nutrition and Clinical Research, Institute of Seafood Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"16742","DOI":"10.1002\/anie.201814144","article-title":"The Chemistry of Protein Oxidation in Food","volume":"58","author":"Hellwig M.","year":"2019","journal-title":"Angewandte Chemie International Edition"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"19683","DOI":"10.1074\/jbc.REV119.006217","article-title":"Detection, identification, and quantification of oxidative protein modifications","volume":"294","author":"Hawkins C. 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