{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:24:08Z","timestamp":1792445048585,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472948"],"award-info":[{"award-number":["32472948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20255"],"award-info":[{"award-number":["U21A20255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Heat stress (HS) induces adverse intestinal effects, including morphological damage, immune dysfunction, and microbial dysbiosis. Nicotinamide riboside (NR) supplementation has shown promise in protecting against intestinal injury. This study aimed to investigate the efficacy of NR in alleviating HS\u2010induced intestinal damage in a porcine model. Eighteen boars were randomized into three groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06): control (CON, thermoneutral), heat stress (HS), and HS with NR supplementation (HS\u2010NR). After an initial feeding phase, the HS and HS\u2010NR groups were exposed to an HS environment (35 \u00b1 1\u00b0C) for 2 weeks, while the CON group remained thermoneutral. Intestinal injury was assessed via histomorphology, biochemical parameters, transcriptomics, and microbiome sequencing. We found that NR supplementation significantly restored intestinal morphology and attenuated colonic oxidative stress compared to the HS group. Moreover, NR ameliorated HS\u2010induced immune dysfunction and corrected gut microbial dysbiosis. These results suggest the therapeutic potential of NR as a nutritional intervention to mitigate HS\u2010induced intestinal damage.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70418","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:29:18Z","timestamp":1772998158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nicotinamide Riboside Alleviates Heat Stress\u2010Induced Intestinal Dysfunction by Enhancing Antioxidant Capacity, Restoring Immune Homeostasis, and Modulating Gut Microbiota in a Boar Model"],"prefix":"10.1002","volume":"70","author":[{"given":"Xianyang","family":"Jin","sequence":"first","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihao","family":"Luo","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxue","family":"Shen","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Lv","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Feeder Biotechnology (Sichuan) Co., Ltd.  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Jin","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Feng","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqiang","family":"Che","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Wu","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Hua","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition of Sichuan Province Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03395-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617526114"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8547379"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030734"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-024-10928-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11041135"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-6759"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.144568"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"437","article-title":"Intestinal Inflammation and Tissue Injury in Response to Heat Stress and Cooling Treatment in Mice","volume":"4","author":"Liu Z.","year":"2011","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.686902"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.706772"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12948"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.043"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70162"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010174"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061230"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000002628"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.010"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi4862"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115626254"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.11.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-022-00783-3"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2008-1339"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820130116"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.52339"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-15-0161"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-070119-115104"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-021-02083-3"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731114001268"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010073"},{"issue":"3","key":"e_1_2_11_40_1","first-page":"363","article-title":"Transforming Growth Factor\u2010Beta: A General Review","volume":"7","author":"Lawrence D.","year":"1996","journal-title":"European Cytokine Network"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122612"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.717723"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12088-021-00948-0"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO00886F"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11102580"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00655"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO05221D"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:40:56Z","timestamp":1773337256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/mnfr.70418"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70418","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"2025-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70418"}}