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In this study, two indigenous\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    , LpJ5 and LpJ8, were evaluated for their anti\u2010inflammatory and neuroprotective properties to mitigate oxidative stress and enhance cell viability in neuroinflammatory models. Results indicate that LpJ5 significantly upregulated glutathione peroxidase (gpx) and glutathione (gsh) expression at 0.9\u00a0mM hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ). The probiotic strains also demonstrated significant anti\u2010inflammatory effects in lipopolysaccharide (LPS)\u2010induced BV2 and SH\u2010SY5Y cell models. Pretreatment with LpJ5 resulted in a 59.7% reduction in nitric oxide (NO) production in BV2 cells and a 56.7% reduction in SH\u2010SY5Y cells. LpJ8 showed comparable reductions of 49.2% and 47.3%, respectively. Additionally, LpJ5 pretreatment led to an increase in cell viability in BV2 and SH\u2010SY5Y cells. Both strains also reduced the expression of inflammatory markers such as iNOS, COX\u20102, TNF\u2010\u03b1, IL\u20101\u03b2, and upregulated BCL\u20102 and IL\u201010, with LpJ5 exhibiting stronger effects, particularly in the pretreatment phase. These findings demonstrate the antioxidant and anti\u2010inflammatory capabilities of LpJ5 and LpJ8 and thereby highlight potential mechanistic links and lay the groundwork for subsequent translational and clinical investigations. Thus making them promising candidates for therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70422","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:28:47Z","timestamp":1772990927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Inflammatory and Neuroprotective Potential of Indigenous\n                    <i>Lactiplantibacillus Plantarum<\/i>\n                    Strains"],"prefix":"10.1002","volume":"70","author":[{"given":"Nabendu","family":"Debnath","sequence":"first","affiliation":[{"name":"Centre for Molecular Biology Central University of Jammu, Samba Jammu &amp; Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Yadav","sequence":"additional","affiliation":[{"name":"Centre for Molecular Biology Central University of Jammu, Samba Jammu &amp; Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Health Sciences Centre University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Mehta","sequence":"additional","affiliation":[{"name":"Centre for Molecular Biology Central University of Jammu, Samba Jammu &amp; Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munna Lal","family":"Yadav","sequence":"additional","affiliation":[{"name":"Discovery Research Division Indian Council of Medical Research (ICMR)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Zoology Central University of Jammu, Samba Jammu &amp; Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1439125"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001486\u20105"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.10.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080743"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010022\u201002565\u20100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010017\u20100933\u20103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081482"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001911\u20103"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081583"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1347987"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.69857\/joapr.v12i5.648"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12450"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010024\u201003988\u2010x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13111663"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8063647"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13223676"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12088\u2010023\u201001129\u2010x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9070610"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030769"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.89894"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2018\u201016197"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.00608\u201023"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8010079"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602\u2010021\u201009781\u20109"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201001959\u20102"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.21736"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068\u2010020\u201000830\u20107"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20109525(00)89052\u20106"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010024\u201001494\u20101"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112646"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010021\u201002767\u2010y"},{"key":"e_1_2_11_33_1","unstructured":"O. 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