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We assessed the safety and tolerability of XN in adults with Crohn's disease (CD) over 8 weeks. In this randomized, triple\u2010masked, placebo\u2010controlled phase 2 trial, 20 adults with unremitted CD received either 24\u00a0mg\/day XN or placebo for 8 weeks. Primary outcomes included clinical laboratory toxicology parameters, vital signs and adverse events (AEs). Disease activity was screened and assessed using the Crohn's Disease Activity Index (CDAI). XN was well tolerated, with adherence exceeding 95%. Neither halting nor stopping criteria were met, and all laboratory elevations were minor and transient in both groups. There were no attributable serious AEs in either group, and all moderate AEs were short\u2010term and self\u2010resolving. Between\u2010group comparisons demonstrated differences for changes in BMI and gamma\u2010glutamyltransferase (GGT), favoring XN: BMI: \u22120.67 (0.0, 1.3),\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04 and GGT: \u22124.8\u00a0U\/L, 95% CI 0.8\u20138.8,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02, which may reflect beneficial effects on hepatic and metabolic health in CD. XN at 24\u00a0mg\/day was safe and well tolerated in adults with active CD, supporting further research in inflammatory bowel disease.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70438","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:23:06Z","timestamp":1773638586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple\u2010Masked, Randomized, Placebo\u2010Controlled Phase 2 Trial"],"prefix":"10.1002","volume":"70","author":[{"given":"Ryan","family":"Bradley","sequence":"first","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Sciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"A. Staab","sequence":"additional","affiliation":[{"name":"Helfgott Research Institute National University of Natural Medicine  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"E. Jamieson","sequence":"additional","affiliation":[{"name":"College of Health Oregon State University  Corvallis Oregon USA"},{"name":"Linus Pauling Institute Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"O. Langley","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"O. Metz","sequence":"additional","affiliation":[{"name":"Biological Sciences Division Pacific Northwest National Laboratory  Richland Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"F. Stevens","sequence":"additional","affiliation":[{"name":"Linus Pauling Institute Oregon State University  Corvallis Oregon USA"},{"name":"Department of Pharmaceutical Sciences Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06782-z"},{"key":"e_1_2_9_3_1","article-title":"Medical Management of Crohn's Disease","volume":"12","author":"Gade A. 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