{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:20:18Z","timestamp":1783012818545,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. Xanthohumol (XN) exhibits anti\u2010inflammatory, anti\u2010oxidant, anti\u2010fibrotic, anti\u2010microbial, anti\u2010proliferative, and immunomodulatory effects that all are associated with the IgAN pathogenesis. Our study aims to evaluate the potential impact of XN on the clinical course of IgAN refractory to conventional treatment. Included were five rigorously selected IgAN patients with poor prognosis assessed on the basis of clinical findings and renal biopsy. Patients received XN orally at a daily dose of 2\u00a0mg\/kg body weight. Biochemical tests were performed the day before the start of XN administration, and then after 2, 4, 12, 24, and 52 weeks of XN administration. XN induced a decrease in daily proteinuria in all patients. Compared to baseline values, at T52 the mean reduction in proteinuria and albumin\u2010creatinine\u2010ratio was 45.3% and 48.4% respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001 in both cases). Reduction of urine erythrocyturia occurred in four out of five patients. No progression of chronic kidney disease was observed in any patient. No adverse effects of XN were observed, and XN was well tolerated. XN supplementation has potential as an additive treatment for IgAN patients. Moreover, XN appears to be safe and well tolerated.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70439","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:45:28Z","timestamp":1773337528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beneficial Effect of Xanthohumol Supplementation on the Clinical Course of IgA Nephropathy Refractory to Conventional Treatment\u2014A Prospective, Open\u2010Label Case Series"],"prefix":"10.1002","volume":"70","author":[{"given":"Andrzej","family":"Jaroszy\u0144ski","sequence":"first","affiliation":[{"name":"Collegium Medicum Department of Internal Medicine and Family Medicine Jan Kochanowski University in Kielce  Kielce Poland"},{"name":"Department of Nephrology Regional Hospital of Stalowa Wola  Stalowa Wola Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Dabrowski","sequence":"additional","affiliation":[{"name":"First Department of Anaesthesiology and Intensive Therapy Medical University in Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Gago\u015b","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Maria Curie\u2010Sklodowska University Akademicka 19 Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Perkowska\u2010Ptasi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and the Linus Pauling Institute Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.11.026"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010024\u201000885\u20103"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0002382022"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.021"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2004.04.025"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2315633"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108766"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114082"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4043"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11963"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00171"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061112"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12558"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201082967\u2010x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010021\u201002653\u2010y"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08600718"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae085"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017010108"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad232"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018101017"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.08.009"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040932"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.023"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111238"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012702"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/spcare\u20102024\u2010004984"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2010011666"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.07.041"}],"container-title":["Molecular Nutrition &amp; 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