{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:30:28Z","timestamp":1792801828190,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173513"],"award-info":[{"award-number":["82173513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773426"],"award-info":[{"award-number":["81773426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gestational hypertension (GH) is a common pregnancy complication associated with long\u2010term cardiovascular risks in both mothers and offspring. Polyphenols, widely present in plant\u2010based foods, exhibit antioxidant and anti\u2010inflammatory properties, but their relationship with GH risk remains insufficiently understood. GH risk remains unclear. This study included 2160 participants from the Tongji Birth Cohort. Dietary intake during early pregnancy was assessed using a validated food frequency questionnaire, and polyphenol intake was estimated using standardized databases. GH was defined as systolic or diastolic blood pressure \u2265 140\/90\u00a0mmHg after 20 weeks of gestation in previously normotensive women. Multivariable logistic regression and restricted cubic spline analyses demonstrated nonlinear inverse associations between total and subclass\u2010specific polyphenol intake and GH risk, with risk reductions plateauing at moderate\u2010to\u2010high intake levels (approximately 450\u00a0mg\/day for total polyphenols, 300\u00a0mg\/day for flavonoids, and 80\u00a0mg\/day for phenolic acids). Fruit\u2010derived polyphenols contributed most strongly. Mediation analyses indicated that the systemic immune\u2010inflammation index partially mediated the associations of total polyphenols (8.19%) and flavonoids (8.04%) with GH risk. Higher maternal polyphenol intake, particularly from fruits, was associated with lower GH risk, partly mediated by systemic inflammation.<\/jats:p>","DOI":"10.1002\/mnfr.70440","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:43:34Z","timestamp":1773639814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal Polyphenol Intake and Gestational Hypertension: Nonlinear Associations and Inflammatory Mediation"],"prefix":"10.1002","volume":"70","author":[{"given":"Hongjuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanghua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene Tongji Medical College Huazhong University of 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