{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:15:48Z","timestamp":1781507748718,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Portulaca oleracea<\/jats:italic>\n                    L. (purslane) is a widely cultivated herb with edible and medicinal value. Modern pharmacological studies have shown that purslane has potent anti\u2010inflammatory effects. However, its potential role in ameliorating atherosclerosis remains unclear. This study aimed to investigate the efficacy of purslane extract in ameliorating atherosclerosis in apolipoprotein E(ApoE) knock\u2010out (ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice. ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice fed a Western diet were administered either purslane ethanol extract (400\u00a0mg\/kg\/day) or a vehicle for 4 weeks. Furthermore, isolated aortas from C57BL\/6J mice were treated with lysophosphatidylcholine (LPC) with or without purslane extract for ex vivo experiments. Oil red O staining, functional study by wire myograph, fluorescence imaging, and Western blotting were performed. Purslane extract normalized plasma lipid profiles, reducing total cholesterol, triglycerides, and LDL while increasing HDL in ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. It also reduced plasma interleulin\u20106 concentration. Purslane extract reduced atherosclerotic plaque area and ROS accumulation in aortas. Purslane extract improved endothelium\u2010dependent relaxations (EDRs) in ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mouse aortas and LPC\u2010treated mouse aortas. Protein expression analysis indicated that purslane extract suppressed vascular inflammation by suppressing the MAPK pathway and enhanced vasorelaxation by activating the AMPK\/PI3K\/Akt\/eNOS pathway. These findings suggest that purslane extract is promising for inhibiting vascular inflammation and retarding the progression of atherosclerosis.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70449","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:44:42Z","timestamp":1774673082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Purslane (\n                    <i>Portulaca oleracea<\/i>\n                    L.) Extract Alleviates Atherosclerosis in ApoE\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mice"],"prefix":"10.1002","volume":"70","author":[{"given":"Yuehan","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Chinese Medical Sciences State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Sciences State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Sciences State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanshan","family":"Yu","sequence":"additional","affiliation":[{"name":"Sericultural &amp; Agri\u2010Food Research Institute Guangdong Academy of Agricultural Sciences\/Key Laboratory of Functional Foods Ministry of Agriculture and Rural Affairs\/Guangdong Key Laboratory of Agricultural Products Processing  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manqin","family":"Fu","sequence":"additional","affiliation":[{"name":"Sericultural &amp; Agri\u2010Food Research Institute Guangdong Academy of Agricultural Sciences\/Key Laboratory of Functional Foods Ministry of Agriculture and Rural Affairs\/Guangdong Key Laboratory of Agricultural Products Processing  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai San","family":"Cheang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Sciences State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau Macau SAR 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