{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:52:17Z","timestamp":1777283537521,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diarrhea\u2010predominant irritable bowel syndrome (IBS\u2010D) is a multifactorial disorder involving gut\u2010brain axis dysregulation, altered barrier integrity, microbial imbalance, and stress\u2010related mechanisms, with limited nutritional strategies targeting these pathways. Tannin\u2010rich extracts may exert barrier\u2010protective, microbiota\u2010modulating, and stress\u2010related effects.<\/jats:p>\n                  <jats:p>In a prospective before\u2010after pilot study (NCT05207618), 28 adults with IBS\u2011D completed a 60\u2011day tannin\u2010based supplementation (480\u00a0mg\/day). Outcomes included IBS Severity Scoring System (IBS\u2010SSS), bowel habits, somatization, perceived stress, serum zonulin, faecal short\u2010chain fatty acids, and hydrogen breath test. Linear mixed models assessed changes over time.<\/jats:p>\n                  <jats:p>\n                    IBS\u2010SSS decreased by an estimated mean of 70 points (95% CI: 34\u2013107;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001); stool consistency improved by 1.38 (95% CI: 0.72 to 2.05;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), and bowel movements\/day decreased by 0.84 (95% CI: 0.08 to 1.71;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.028). Somatization and stress scores declined significantly (both\n                    <jats:italic>P<\/jats:italic>\n                    \u2264 0.003). Zonulin dropped (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u00a00.0001), butyrate increased (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001), and propionate decreased (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.017). Hydrogen\u2010positive subjects at baseline (3\/28) were all negative at 60 days. No adverse events occurred.\n                  <\/jats:p>\n                  <jats:p>This pilot suggests a tannin\u2010based phytocomplex may improve gastrointestinal and psychological symptoms in IBS\u2010D, with biomarker changes indicating enhanced barrier function and microbial metabolism. Larger trials are warranted.<\/jats:p>","DOI":"10.1002\/mnfr.70451","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:46:31Z","timestamp":1776674791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tannin Phytocomplex Improves IBS\u2010D Symptoms and Gut\u2010Brain Markers: Prospective Pilot Study"],"prefix":"10.1002","volume":"70","author":[{"given":"Silvia","family":"Molino","sequence":"first","affiliation":[{"name":"Silvateam Spa R&amp;D Unit  San Michele Mondov\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda M.","family":"Piskorz","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Hospital de Cl\u00ednicas Jos\u00e9 de San Martin Sector Neurogastroenterolog\u00eda del Servicio de Gastroenterolog\u00eda  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Lerma\u2010Aguilera","sequence":"additional","affiliation":[{"name":"University of Lund Neuroinflammation  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana L\u00f3pez","family":"Mingorance","sequence":"additional","affiliation":[{"name":"Universidad de Buenos aires\/ IBIMOL Hospital de Cl\u00ednicas Jos\u00e9 de San Martin Programa de Estudios Pancre\u00e1ticos  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cielo","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Hospital de Cl\u00ednicas Jos\u00e9 de San Martin Sector Neurogastroenterolog\u00eda del Servicio de Gastroenterolog\u00eda  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Montero","sequence":"additional","affiliation":[{"name":"Universidad de Buenos 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