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Therefore, we here present a human pilot study with a novel dual isotope design to assess the bioavailability of brewer's yeast folate as a model food. The particular advantage of the study design is the use of yeast intrinsically labeled with N\u201015, and a new reference folate specifically labeled with C\u201013. In this trial, 6 volunteers consumed (1) the intrinsically\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010labeled yeast, (2) a\n                    <jats:sup>13<\/jats:sup>\n                    C\n                    <jats:sub>6<\/jats:sub>\n                    \u2010labeled (6S)\u20105\u2010methyltetrahydrofolate as the reference dose and (3) a folate\u2010free food on one of the three study days. On each study day, 21 plasma samples were taken and analyzed for three different isotopologues of (6S)\u20105\u2010methyltetrahydrofolate using a\n                    <jats:sup>13<\/jats:sup>\n                    C\n                    <jats:sub>5<\/jats:sub>\n                    \u2010labeled (6S)\u20105\u2010methyltetrahydrofolate as quantitation standard in stable isotope dilution assays. The main outcome of the study was that the yeast folates revealed for the five assessed volunteers a mean bioavailability of 74 % relative to 5\u2010methyltetrahydrofolate as the reference dose. The study allows to conclude that intrinsically labeled foods are best suited to accurately measure the bioavailabilities of natural food folates embedded in their natural food matrix.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70453","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:02:32Z","timestamp":1775732552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Determination of Folate Bioavailability From Brewer's Yeast in a Dual Isotope Randomized Human Intervention Study"],"prefix":"10.1002","volume":"70","author":[{"given":"Nadine","family":"Weber","sequence":"first","affiliation":[{"name":"Chair of Analytical Food Chemistry Technical University of Munich  Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Striegel","sequence":"additional","affiliation":[{"name":"Chair of Analytical Food Chemistry Technical University of Munich  Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Methner","sequence":"additional","affiliation":[{"name":"Research Center Weihenstephan for Brewing and Food Quality Technical University of Munich Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Brandl","sequence":"additional","affiliation":[{"name":"ZIEL, Institute for Food &amp; Health, Core Facility Human Studies Technical University of Munich  Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Groehn","sequence":"additional","affiliation":[{"name":"Merck &amp; Cie KmG  Schaffhausen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Knapp","sequence":"additional","affiliation":[{"name":"Merck &amp; Cie KmG  Schaffhausen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Skurk","sequence":"additional","affiliation":[{"name":"ZIEL, Institute for Food &amp; Health, Core Facility Human Studies Technical University of Munich  Freising Germany"},{"name":"Technical University of Munich, School of Medicine and Health Klinikum Rechts Der Isar  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rychlik","sequence":"additional","affiliation":[{"name":"Chair of Analytical Food Chemistry Technical University of Munich  Freising Germany"},{"name":"Centre For Nutrition and Food Sciences University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.206599"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01622223"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11071114"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-0043-114481","article-title":"Folat und Fols\u00e4ure","volume":"32","author":"Szabolcs P.","year":"2017","journal-title":"e&m\u2014Ern\u00e4hrung und Medizin"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102014\u20100346"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326\u20105377.2008.tb02183.x"},{"key":"e_1_2_11_8_1","unstructured":"World Health OrganisationFlour Fortification: Reporting Accomplishments: Report of a Joint WHO\/UNICEF\/MI Intercountry Technical Review Meeting on Flour Fortification Cairo Egypt(2003) 17 presented at."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0379572118774229"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13527"},{"key":"e_1_2_11_11_1","volume-title":"Nutzen\u2010Risiko\u2010Abw\u00e4gung Einer Fl\u00e4chendeckenden Anreicherung von Mehl mit Fols\u00e4ure: Stellungnahme Nr. 027\/2017 Des BfR vom 13","author":"Bundesinstitut f\u00fcr Risikobewertung","year":"2017"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.29252\/JABR.06.04.01"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1252497"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2024.110895"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation5020051"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.12.003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2004383"},{"key":"e_1_2_11_18_1","first-page":"336","article-title":"Folat","volume":"6","author":"Heseker H.","year":"2007","journal-title":"Ern\u00e4hrungs Umschau"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00101"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.4.1376S"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.7.1786"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.8.1456"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu3040475"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00658E"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212255"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","unstructured":"EFSA NDA Panel (EFSA Panel on Dietetic Products Nutrition and Allergies) Scientific Opinion on Dietary Reference Values for folate. 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