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A Western\u2010style diet (WD) was used to induce NASH in C57BL\/6J male mice for 16 weeks. Mice then received EA (100\u00a0mg\/kg\/day, oral gavage, 5 days\/week) and\/or 5% inulin (w\/w in diet) for 12 weeks while continuing WD. Inulin increased energy intake and trended toward higher body weight and fasting glucose. EA reduced liver weights and restored the liver\u2010to\u2010body weight ratio. EA and inulin combined significantly reduced steatosis and hepatocyte ballooning, while EA alone reduced liver inflammation and improved biomarkers. In contrast, inulin alone worsened several liver parameters and increased LDL serum levels. EA, alone or combined with inulin, significantly reduced LDL. EA\u2010treated groups showed elevated urinary 3'\u2010methylellagic acid. Importantly, the combination of EA and inulin significantly increased urolithin A, C, and D, indicating enhanced EA metabolism and postbiotic production. While inulin alone exacerbated NASH features, EA significantly improved liver health. The combination of EA and inulin offset the adverse effects of inulin but did not further enhance the therapeutic efficacy of EA.<\/jats:p>","DOI":"10.1002\/mnfr.70456","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:32:03Z","timestamp":1775802723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach to Enhance Therapeutic Potential in Nonalcoholic Steatohepatitis"],"prefix":"10.1002","volume":"70","author":[{"given":"Tharani","family":"Senavirathna","sequence":"first","affiliation":[{"name":"Centre For Precision Health School of Medical and Health Edith Cowan University  Joondalup Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armaghan","family":"Shafaei","sequence":"additional","affiliation":[{"name":"School of Science Edith Cowan University  Joondalup Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricky R.","family":"Lareu","sequence":"additional","affiliation":[{"name":"Curtin Medical School Faculty of Health Sciences and Curtin Medical Research Institute Curtin University  Bentley Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Balmer","sequence":"additional","affiliation":[{"name":"Centre For Precision Health School of Medical and Health Edith Cowan University  Joondalup Western Australia"},{"name":"Centre For Diabetes Research Harry Perkins Institute For Medical Research University of Western Australia  Nedlands Western Australia"},{"name":"Dobney Hypertension Centre, School of Medicine, Royal Perth Hospital Unit, Faculty of Medicine, Dentistry &amp; Health Sciences The University of Western Australia  Perth Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.103910"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.036"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20973"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i42.15539"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31518"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-00938-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158462"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.08.009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32517\u20106"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155835"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020494"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/compounds3010005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12899"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.04.008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0633-9492"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13040485"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.04.027"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/270418"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf5024615"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500901"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.012575"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.07.006"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010018\u20103310\u20103"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","unstructured":"A. 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