{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:12:05Z","timestamp":1783944725915,"version":"3.55.0"},"reference-count":82,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The impact of diet during pregnancy on birth outcomes and child health is well established, and epigenetic changes may be one mechanism underlying such associations, but the role of meal timing (chrono\u2010nutrition) is unclear. We conducted an epigenome\u2010wide association study (EWAS) of maternal meal timing and placental DNAm (plaDNAm). Data came from 389 pregnant women in the Barcelona Life Study Cohort (BiSC). Chrono\u2010nutrition and dietary data were collected at 20 weeks of pregnancy, and plaDNAm at delivery was characterized using the Illumina EPIC array. Linear robust regression models tested associations between five chrono\u2010nutritional behaviors (time of first and last meal, nighttime fasting duration, number of eating occasions, and eating jetlag) and plaDNAm. We identified 7 CpGs significantly associated with time of last meal (Bonferroni\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 1E\u201008) and 63 suggestive CpGs (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 1E\u201005). Hits included cg13147785 (\n                    <jats:italic>E2F8<\/jats:italic>\n                    ), linked to placental cell cycle regulation, cg17665505 (\n                    <jats:italic>DAP<\/jats:italic>\n                    ) and cg18303215 (\n                    <jats:italic>ABCG5<\/jats:italic>\n                    ), associated with smoking and lung diseases in adults. To conclude, maternal chrono\u2010nutrition was associated with some CpGs in the placenta, particularly time of last meal. Further studies are needed to clarify how meal timing may influence fetal development and long\u2010term health through epigenetic mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70465","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:53:11Z","timestamp":1777445591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Chrono\u2010Nutrition and Placental DNA Methylation: The BiSC Study"],"prefix":"10.1002","volume":"70","author":[{"given":"Joana","family":"Llaurad\u00f3\u2010Pont","sequence":"first","affiliation":[{"name":"ISGlobal  Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Aguilar\u2010Lacasa\u00f1a","sequence":"additional","affiliation":[{"name":"ISGlobal  Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF)  Barcelona Spain"},{"name":"CIBER Epidemiology and Public Health (CIBERESP) Instituto De Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cosin\u2010Tomas","sequence":"additional","affiliation":[{"name":"ISGlobal  Barcelona Spain"},{"name":"CIBER Epidemiology and Public Health (CIBERESP) Instituto De Salud Carlos III  Madrid Spain"},{"name":"Barcelona InTerdisciplinary research group on plAnetary heaLth (BITAL), Faculty of Health Sciences Universitat Oberta de Catalunya (UOC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Julvez","sequence":"additional","affiliation":[{"name":"ISGlobal  Barcelona Spain"},{"name":"Clinical and Epidemiological Neuroscience (Neuro\u00c8pia) Institut D'investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Reus 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