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Early\u2010life exposure to maternal overnutrition during critical developmental windows, such as lactation, can predispose offspring to develop metabolic disease. We previously demonstrated that consumption of a high fat diet (60% fat) during lactation leads to the development of insulin resistance and MASLD in male offspring. However, no studies have investigated the role of a lactational Western\u2010style fat (45% fat) exposure, which is more clinically relevant and representative of human food consumption habits. Dams were fed either a standard chow or Western\u2010style fat diet from delivery through the 21\u2010day lactation period. At weaning, all offspring were fed standard chow until 3 months of age, when a subset from each group was challenged with an additional high\u2010fat stressor. Exposure to a Western\u2010style fat diet during lactation increased male offspring susceptibility to weight gain, obesity, and insulin resistance when fed a high fat diet in adulthood. Furthermore, these offspring demonstrated hepatomegaly and hepatic triglyceride accumulation, which may be mediated by altered lipid metabolism. These findings indicate that an indirect neonatal exposure to a Western\u2010style fat diet can program male offspring to develop MASLD later in life.<\/jats:p>","DOI":"10.1002\/mnfr.70468","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:09:38Z","timestamp":1776420578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactational Western\u2010Style Fat Exposure in Mice Programs Metabolic Dysfunction\u2010Associated Steatotic Liver Disease (MASLD) in Male Offspring"],"prefix":"10.1002","volume":"70","author":[{"given":"Amy Y.","family":"Zhao","sequence":"first","affiliation":[{"name":"University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Epidemiology School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oyewale","family":"Shiyanbola","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Bridges","sequence":"additional","affiliation":[{"name":"Nutritional Sciences School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigid","family":"Gregg","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Michigan Medicine  Ann Arbor Michigan USA"},{"name":"Nutritional Sciences School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0431"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010020\u201000570\u2010y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.54707"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010017\u20100806\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp158"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496471"},{"key":"e_1_2_11_9_1","article-title":"Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life","volume":"2015","author":"Li M.","year":"2015","journal-title":"BioMed Research International"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.12.011"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13482"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201017\u20100780"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061393"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.59.384"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.759690"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2015.02.007"},{"key":"e_1_2_11_17_1","unstructured":"CDC Table McrNutr. 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