{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:52:09Z","timestamp":1777283529774,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Celiac disease (CeD) is an autoimmune\u2010mediated disorder triggered by gluten ingestion. Strict adherence to a gluten\u2010free diet (GFD) is currently the only available treatment, yet it presents nutritional and lifestyle challenges. Polyphenols and other bioactive food compounds have shown potential in modulating inflammation and gut health. This study evaluated the impact of cocoa, a polyphenol\u2010rich food, on CeD pathogenesis in a preclinical model. DQ8\u2010D\n                    <jats:sup>d<\/jats:sup>\n                    \u2010villin\u2010IL\u201015tg mice with predisposition to CeD were fed either a GFD (REF), a gluten\u2010containing diet (GLI), or a gluten\u2010containing diet supplemented with cocoa (GLI+COCOA) for 25 days. Outcomes assessed included intestinal histology, antibody (Ab) levels, cytokine and immunoglobulin profiles and mesenteric lymph node lymphocytes\u2019 phenotypes. Cocoa administration limited gluten\u2010induced intestinal villous atrophy and reduced anti\u2010gliadin Abs, while significantly decreasing the secretion of pro\u2010inflammatory cytokines. Moreover, cocoa normalized the Ig isotype profile dysregulated by gluten intake. Cocoa intake exerts a protective effect against key hallmarks of CeD, attenuating inflammation and limiting the damage to the intestinal structure. These findings support cocoa as a promising complementary dietary strategy to modulate CeD\u2010related manifestations, although additional translational studies are warranted\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70472","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:46:46Z","timestamp":1776674806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cocoa Attenuates Gluten\u2010induced Pathogenesis in a Preclinical Model of Celiac Disease"],"prefix":"10.1002","volume":"70","author":[{"given":"Marina","family":"Girbal\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Section of Physiology Department of Biochemistry and Physiology Faculty of Pharmacy and Food Science Universitat De Barcelona  Barcelona Spain"},{"name":"Research Institute of Nutrition and Food Safety (INSA\u2010UB) Universitat De Barcelona  Santa Coloma de Gramenet Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Rodr\u00edguez\u2010Lagunas","sequence":"additional","affiliation":[{"name":"Section of Physiology Department of Biochemistry and Physiology Faculty of Pharmacy and Food Science Universitat De Barcelona  Barcelona Spain"},{"name":"Research Institute of Nutrition and Food Safety (INSA\u2010UB) Universitat De Barcelona  Santa Coloma de Gramenet Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Rodr\u00edguez\u2010Banqueri","sequence":"additional","affiliation":[{"name":"Proteolysis Laboratory Department of Structural and Molecular Biology Molecular Biology Institute of Barcelona (IBMB) Higher Scientific research Council (CSIC)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Eckhard","sequence":"additional","affiliation":[{"name":"Synthetic Structural Biology Department of Structural and Molecular Biology Molecular Biology Institute of Barcelona (IBMB) Higher Scientific research Council (CSIC)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Xavier","family":"Gomis\u2010R\u00fcth","sequence":"additional","affiliation":[{"name":"Proteolysis Laboratory Department of Structural and Molecular Biology Molecular Biology Institute of Barcelona (IBMB) Higher Scientific research Council (CSIC)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c0ngels","family":"Franch\u2010Masferrer","sequence":"additional","affiliation":[{"name":"Section of Physiology Department of Biochemistry and Physiology Faculty of Pharmacy and Food Science Universitat De Barcelona  Barcelona Spain"},{"name":"Research Institute of Nutrition and Food Safety (INSA\u2010UB) Universitat De Barcelona  Santa Coloma de Gramenet Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"P\u00e9rez\u2010Cano","sequence":"additional","affiliation":[{"name":"Section of Physiology Department of Biochemistry and Physiology Faculty of Pharmacy and Food Science Universitat De Barcelona  Barcelona 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