{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:51:37Z","timestamp":1777283497030,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Cordyceps militaris<\/jats:italic>\n                    , a traditional medicinal fungus and a promising food supplement, has demonstrated anticancer potential, yet its underlying mechanisms and in vivo efficacy remain poorly defined. Previously, we developed an optimized extraction and preparation protocol to enrich the bioactive content of\n                    <jats:italic>C. militaris<\/jats:italic>\n                    , specifically adenosine and cordycepin. Here, using this optimized\n                    <jats:italic>C. militaris<\/jats:italic>\n                    extract (CME), we investigated its antitumor effects and underlying mechanisms in a murine lung cancer model. Components of CME were quantified using high\u2010performance liquid chromatography. In vivo, CME significantly suppressed tumor growth in LLC1\u2010bearing mice. Mechanistically, CME induced ferroptosis, an iron\u2010dependent form of regulated cell death characterized by lipid peroxidation and redox imbalance. Tumors from CME\u2010treated mice displayed elevated lipid ROS, increased iron accumulation, glutathione depletion, and downregulation of glutathione peroxidase 4. Apoptotic signaling was accompanied with ferroptosis, but neither pyroptosis nor necroptosis contributed to CME\u2010induced lung cancer death. Pharmacological rescue experiments confirmed the specificity of ferroptosis as the dominant mode of cell death. Importantly, CME caused no systemic toxicity, and its approximate lethal dose was over 5000\u00a0mg\/kg. Together, these findings suggest CME as a potent ferroptosis\u2010inducing agent against lung cancer and establish\n                    <jats:italic>C. militaris<\/jats:italic>\n                    as a promising candidate for redox\u2010targeted cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70477","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:04:32Z","timestamp":1777100672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cordycepin\u2010Enriched\n                    <i>Cordyceps militaris<\/i>\n                    Extract ARA815 Induces Ferroptosis in Lung Cancer Cells In Vivo and In Vitro"],"prefix":"10.1002","volume":"70","author":[{"given":"Mina","family":"Boo","sequence":"first","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Heon","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HyoJeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Bioara Co., Ltd  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harim","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhyeon","family":"An","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HyunSoo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Hyun","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biological Sciences College of Science Nanyang Technological University  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Bioara Co., Ltd  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Wonkwang Medical Science and Department of Microbiology Wonkwang University School of Medicine  Iksan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Biochemistry College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woojin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Physiology College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan\u2010Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immune and Respiratory System Department of Internal Medicine College of Korean Medicine Kyung Hee University Kyung Hee University Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Herbal Pharmacology College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Lin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Pharmacology College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1330","article-title":"Lung Cancer Statistics","volume":"2024","author":"Kratzer T. 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