{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:51:41Z","timestamp":1777283501356,"version":"3.51.4"},"reference-count":120,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["341475"],"award-info":[{"award-number":["341475"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Evidence suggests that neuropathic pain (NP) and comorbid mood disorders are associated with circadian abnormalities. This suggests a role for chronotherapies, such as time\u2010restricted feeding (TRF), to alleviate pain and comorbid anxiety. We investigated the effects of TRF on pain and anxiety\u2010related behaviours in spared nerve injury (SNI) mice with NP and diurnal changes in the hypothalamus transcriptome, an important hub for modulating fear and anxiety. SNI male and female C57BL\/6JRj mice received TRF during the dark active phase or ad libitum feeding (ALF) for three weeks post\u2010surgery. Behavioral tests, von Frey, hot plate, light\u2010dark box (LDT), and open field (OFT), were performed at baseline and post\u2010surgery; hypothalamus tissues were dissected in the morning (zeitgeber time (ZT) 2\u20136) and afternoon (ZT 8\u201312). Male, but not female, SNI mice under TRF showed significantly reduced anxiety\u2010like behaviors (LDT:\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.0259, Cohen's d\u00a0=\u00a01.245; OFT:\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.0054, Cohen's d\u00a0=\u00a01.643). Differentially expressed gene (DEG) analysis identified 33 DEGs in the hypothalamus in male SNI mice between TRF and ALF in the afternoon, with enriched anxiety\u2010related, mitochondrial, and circadian genes. These findings support TRF as a potential therapeutic approach to alleviate comorbid anxiety in NP.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70479","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:59:02Z","timestamp":1777100342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010Restricted Feeding Alters Behavior in a Sex\u2010Specific Manner in Mice With Neuropathic Pain"],"prefix":"10.1002","volume":"70","author":[{"given":"Manqing","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"SleepWell Research Programme, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"SleepWell Research Programme, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eija","family":"Kalso","sequence":"additional","affiliation":[{"name":"SleepWell Research Programme, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Pharmacology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinko","family":"Palada","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"SleepWell Research Programme, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.12"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00334.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.08.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148286"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001786"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1109480"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0694-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3627"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.12.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033981"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106934"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21728"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.05.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.12.006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.11.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04884-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24741"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/sexes3010012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3360"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibror.2018.11.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135919"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153128"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04284"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2023.100655"},{"key":"e_1_2_9_26_1","first-page":"3092","article-title":"The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice","volume":"54","author":"Richner M.","year":"2011","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.037"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.05.006"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0465-4"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111982"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2005.07.005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-024-02061-2"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.317905"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20813"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-05031.2003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609916104"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053673"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2008.00455.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.12.033"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703056"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-01046-7"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-11-03771.2001"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-27-09097.2003"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.03.004"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710978105"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00090.2011"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233000"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0418"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052706899"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46458-7"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1509370"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.03.046"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02518-y"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2024.101117"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2010.00165"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00835-1"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S473022"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2793-17.2017"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00867-y"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-023-03092-8"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01971-5"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-2-35"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196766"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/35007534"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-021-09751-2"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-19-0153"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.02.001"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3213"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.11.002"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520387113"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5489.131"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.08.029"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6759"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12010"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.10.028"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01341-5"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.03.1050"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003452"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0880-18.2018"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12531"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200006260-00031"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn142"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2630"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.552188"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004238"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00109-w"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-820107-7.00009-4"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70692"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113947"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123770"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106931"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04250"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00216"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509421"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.711065"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105789"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2022.101010"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2017.1369523"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.07.014"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.112873"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.3050"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174611"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08591-6"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113846"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.004"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1034743"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.001"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-021-00149-0"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00128.2018"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.07.002"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2018.05.016"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-7-62"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101583"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.60.111"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133130"},{"key":"e_1_2_9_119_1","article-title":"Current Understanding of the Neural Circuitry in the Comorbidity of Chronic Pain and Anxiety","volume":"15","author":"Chen T.","year":"2022","journal-title":"Neural Plasticity"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141218998"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00284"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70479","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:14:15Z","timestamp":1777281255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":120,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/mnfr.70479"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70479","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70479"}}