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FSE administration improved bone microarchitecture and modulated key markers associated with bone turnover, including reduced CTX\u20101 and RANKL levels and increased OPG expression, indicating suppression of osteoclastogenesis. In addition, FSE enhanced estrogen receptor\u2013related activity and upregulated genes involved in bone metabolism. Notably, FSE also increased estradiol, serotonin, and norepinephrine levels, suggesting a beneficial role in neuroendocrine regulation. 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